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Binaural processing deficit and cognitive impairment in Alzheimer's disease.

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收录情况： ◇ SCIE

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机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China [2]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders,Beijing, China [3]School of Psychological and Cognitive Sciences, Peking University, Beijing, China [4]Speech and Hearing Research Center, Peking University, Beijing, China [5]Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China [6]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China [7]Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany [8]DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany [9]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China [10]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [11]National Clinical Research Center for Geriatric Disorders, Beijing, China [12]Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China [13]Beijing Institute for Brain Disorders, Beijing, China

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关键词： Alzheimer’s disease binaural processing biomarker central auditory processing cognitive impairment

摘要：

Speech comprehension in noisy environments depends on central auditory functions, which are vulnerable in Alzheimer's disease (AD). Binaural processing exploits two ear sounds to optimally process degraded sound information; its characteristics are poorly understood in AD. We studied behavioral and electrophysiological alterations in binaural processing among 121 participants (AD = 27; amnestic mild cognitive impairment [aMCI] = 33; subjective cognitive decline [SCD] = 30; cognitively normal [CN] = 31). We observed impairment of binaural processing in AD and aMCI, and detected a U-shaped curve change in phase synchrony (declining from CN to SCD and to aMCI, but increasing from aMCI to AD). This improvement in phase synchrony accompanying more severe cognitive stages could reflect neural adaptation for binaural processing. Moreover, increased phase synchrony is associated with worse memory during the stages when neural adaptation apparently occurs. These findings support a hypothesis that neural adaptation for binaural processing deficit may exacerbate cognitive impairment, which could help identify biomarkers and therapeutic targets in AD.© 2021 the Alzheimer's Association.

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出版当年[2021]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学

最新[2023]版：

大类 | 1 区

医学

小类 | 1 区临床神经病学

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出版当年[2020]版：

Q1 CLINICAL NEUROLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY

影响因子： 13.1 最新[2023版] 16.1 最新五年平均 21.566 出版当年[2020版] 19.962 出版当年五年平均 17.127 出版前一年[2019版] 16.655 出版后一年[2021版]

第一作者：

第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China

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通讯作者：

通讯机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China [2]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders,Beijing, China [3]School of Psychological and Cognitive Sciences, Peking University, Beijing, China [4]Speech and Hearing Research Center, Peking University, Beijing, China [5]Key Laboratory on Machine Perception (Ministry of Education), Peking University, Beijing, China [6]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China [12]Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China [13]Beijing Institute for Brain Disorders, Beijing, China [*1]Department of Neurology & Innovation Center for Neurological Disorders,Xuanwu Hospital, CapitalMedical University,45 Changchun Street, Beijing 100053, China [*2]School of Psychological and Cognitive Sciences, Peking University, Beijing 100871,China [*3]Department of Neurosurgery,Xuanwu Hospital, CapitalMedical University,45 Changchun Street, Beijing 100053, China.

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Binaural processing deficit and cognitive impairment in Alzheimer's disease.

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