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Education, APOE ɛ4, and Cognition in Individuals with Subjective Cognitive Decline with Worry in the SILCODE Study.

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收录情况： ◇ SCIE ◇ SSCI

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机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [2]Department of Evidence-Based Medicine, Xuanwu Hospital of Capital Medical University, Beijing, China. [3]National Clinical Research Center for Geriatric Disease, Beijing, China.

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Education could offer a protective effect on cognition in individuals with Subjective Cognitive Decline (SCD), which is considered to be the early stage of Alzheimer's Dis- ease (AD). However, the effect of education on cognition in SCD individuals with SCD-plus fea- tures is not clear.The aim of the study was to explore the effect of education on cognition in SCD individ- uals with SCD-plus features.A total of 234 individuals with SCD were included from the Sino Longitudinal Study on Cognitive Decline (SILCODE). Cognition was assessed across 4 domains (memory, executive, lan- guage, and general cognitive functions). Multiple linear regression models were constructed to ex- amine the effect of education on cognitive scores in individuals without worry (n=91) and with wor- ry (n=143). Furthermore, we assessed differences in effects between APOE ε4 noncarriers and APOE ε4 carriers in both groups.Multiple linear regression analysis showed a positive effect of education on memory, ex- ecutive, and language cognition in individuals without worry and all cognitive domains in individu- als with worry. Furthermore, we found a positive effect of education on executive cognition in APOE ε4 noncarriers without worry and language and general cognition in APOE ε4 carriers with- out worry. Meanwhile, education had a positive effect on all cognitive domains in APOE ε4 noncar- riers with worry and executive, language, and general cognition in APOE ε4 carriers with worry.This study indicates that education has the potential to delay or reduce cognitive dec- line in SCD individuals with SCD-plus features.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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出版当年[2020]版：

大类 | 3 区医学

小类 | 3 区临床神经病学 3 区神经科学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区临床神经病学 4 区神经科学

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出版当年[2019]版：

Q2 CLINICAL NEUROLOGY Q3 NEUROSCIENCES

最新[2023]版：

Q3 CLINICAL NEUROLOGY Q4 NEUROSCIENCES

影响因子： 1.8 最新[2023版] 2.9 最新五年平均 3.047 出版当年[2019版] 3.384 出版当年五年平均 3.271 出版前一年[2018版] 3.498 出版后一年[2020版]

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第一作者机构： [1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China.

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