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Senescent immune cells release grancalcin to promote skeletal aging.

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Li Chang-Jun[1,2,3] * ; Xiao Ye[1] ; Sun Yu-Chen[1] ; He Wen-Zhen[1] ; Liu Ling[1] ; Huang Mei[1] ; He Chen[1] ; Huang Min[1] ; Chen Kai-Xuan[1] ; Hou Jing[1] ; Feng Xu[1] ; Su Tian[1] ; Guo Qi[1] ; Huang Yan[1] ; Peng Hui[1] ; Yang M[1] ; Liu Guang-Hui[4,5,6] ; Luo Xiang-Hang[1,2,3,7] ;
机构： [1]Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China [2]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan 410008, China [3]Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Hunan 410008, China [4]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [5]University of Chinese Academy of Sciences, Beijing 100049, China [6]Aging Translational Medicine Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
出处：
DOI： 10.1016/j.cmet.2021.08.009
ISSN：

摘要：
Skeletal aging is characterized by low bone turnover and marrow fat accumulation. However, the underlying mechanism for this imbalance is unclear. Here, we show that during aging in rats and mice proinflammatory and senescent subtypes of immune cells, including macrophages and neutrophils, accumulate in the bone marrow and secrete abundant grancalcin. The injection of recombinant grancalcin into young mice was sufficient to induce premature skeletal aging. In contrast, genetic deletion of Gca in neutrophils and macrophages delayed skeletal aging. Mechanistically, we found that grancalcin binds to the plexin-b2 receptor and partially inactivates its downstream signaling pathways, thus repressing osteogenesis and promoting adipogenesis of bone marrow mesenchymal stromal cells. Heterozygous genetic deletion of Plexnb2 in skeletal stem cells abrogated the improved bone phenotype of Gca-knockout mice. Finally, we developed a grancalcin-neutralizing antibody and showed that its treatment of older mice improved bone health. Together, our data suggest that grancalcin could be a potential target for the treatment of age-related osteoporosis.Copyright © 2021 Elsevier Inc. All rights reserved.

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外文
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中科院(CAS)分区：
出版当年[2020]版：
大类 | 1 区 生物
小类 | 1 区 细胞生物学 1 区 内分泌学与代谢
最新[2023]版：
大类 | 1 区 生物学
小类 | 1 区 细胞生物学 1 区 内分泌学与代谢
JCR分区：
出版当年[2019]版：
Q1 ENDOCRINOLOGY & METABOLISM Q1 CELL BIOLOGY
最新[2023]版：
Q1 CELL BIOLOGY Q1 ENDOCRINOLOGY & METABOLISM

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China [2]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan 410008, China [3]Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Hunan 410008, China
通讯作者：
通讯机构： [1]Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China [2]National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Changsha, Hunan 410008, China [3]Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province, Hunan 410008, China
推荐引用方式(GB/T 7714)：
Li Chang-Jun,Xiao Ye,Sun Yu-Chen,et al.Senescent immune cells release grancalcin to promote skeletal aging.[J].CELL METABOLISM.2021,33(10):1957-+.doi:10.1016/j.cmet.2021.08.009.
APA：
Li Chang-Jun,Xiao Ye,Sun Yu-Chen,He Wen-Zhen,Liu Ling...&Luo Xiang-Hang.(2021).Senescent immune cells release grancalcin to promote skeletal aging..CELL METABOLISM,33,(10)
MLA：
Li Chang-Jun,et al."Senescent immune cells release grancalcin to promote skeletal aging.".CELL METABOLISM 33..10(2021):1957-+

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