机构：[1]Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China,[2]The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China,[3]Department of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China,内科系统老年医学科首都医科大学宣武医院[4]Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin, China,[5]Department of Cardiology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China,[6]Department of Cardiology, Shenzhen People’s Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen, China,深圳市康宁医院深圳市人民医院深圳医学信息中心中国医科大学附属盛京医院[7]Department of Pathophysiology, Shenzhen University, Shenzhen, China,深圳市康宁医院深圳医学信息中心[8]Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Shenzhen, Guang Dong, China
Lipoatrophy is characterized as selective loss of adipose tissues, leading to the severity of cardiovascular disorders. Therefore, there was close intraorgan crosstalk between adipose tissue and cardiovascular in lipoatrophy. A-ZIP/F-1 mouse, a well-established lipoatrophic model, and primary cardiomyocytes were used for investigating the pathophysiological changes and molecular mechanisms. A-ZIP/F-1 mice had severe fat loss and impaired ventricular function during growth, but closely associated with the reduction of circulating vaspin levels. Administration of recombinant vaspin protein improved cardiac structural disorders, left ventricular dysfunction, and inflammatory response in lipoatrophic mice. In detail, vaspin decreased cardiac lipid deposits, but enhanced mitochondrial biogenesis and activities. Interestingly, A-ZIP/F-1 mice transplanted with normal visceral adipose tissues exhibited improvement in cardiac structural remodeling and mitochondrial function. Mechanistically, vaspin increased cardiac AKT activity, which guaranteed the mitochondrial benefits of vaspin in lipoatrophic mice and primary mouse cardiomyocytes. The present study suggested that vaspin possessed biological benefits in attenuating lipoatrophy-induced cardiomyopathy onset, and targeting vaspin/AKT signaling was a potential strategy to maintain heart metabolism.</p>
基金：
National Natural Science
Foundation of China (81800269 and 81800362) and the
Second Affiliated Hospital of Harbin Medical University Youth
Innovation Scientific Research Funding (KYCX2018-24).
第一作者机构：[1]Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China,[2]The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China,[2]The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China,[7]Department of Pathophysiology, Shenzhen University, Shenzhen, China,[8]Guangdong Provincial Key Laboratory of Genome Stability and Disease Prevention, Shenzhen, Guang Dong, China
推荐引用方式(GB/T 7714)：
Zhang Donghui,Zhu Hong,Zhan Enbo,et al.Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice[J].FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY.2021,9:doi:10.3389/fcell.2021.647131.
APA：
Zhang, Donghui,Zhu, Hong,Zhan, Enbo,Wang, Fan,Liu, Yue...&Cao, Wei.(2021).Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice.FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY,9,
MLA：
Zhang, Donghui,et al."Vaspin Mediates the Intraorgan Crosstalk Between Heart and Adipose Tissue in Lipoatrophic Mice".FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 9.(2021)
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