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cGAS- Stimulator of Interferon Genes Signaling in Central Nervous System Disorders

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收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China [2]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China

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关键词： cGAS STING cGAS-STING CNS disorders

摘要：

Cytosolic nucleic acid sensors contribute to the initiation of innate immune responses by playing a critical role in the detection of pathogens and endogenous nucleic acids. The cytosolic DNA sensor cyclic-GMPAMP synthase (cGAS) and its downstream effector, stimulator of interferon genes (STING), mediate innate immune signaling by promoting the release of type I interferons (IFNs) and other inflammatory cytokines. These biomolecules are suggested to play critical roles in host defense, senescence, and tumor immunity. Recent studies have demonstrated that cGAS-STING signaling is strongly implicated in the pathogenesis of central nervous system (CNS) diseases which are underscored by neuroinflammatory-driven disease progression. Understanding and regulating the interactions between cGAS-STING signaling and the nervous system may thus provide an effective approach to prevent or delay late-onset CNS disorders. Here, we present a review of recent advances in the literature on cGAS-STING signaling and provide a comprehensive overview of the modulatory patterns of the cGAS-STING pathway in CNS disorders.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区老年医学

最新[2023]版：

大类 | 2 区医学

小类 | 3 区老年医学

JCR分区：

出版当年[2019]版：

Q1 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q1 GERIATRICS & GERONTOLOGY

影响因子： 7 最新[2023版] 7.1 最新五年平均 5.402 出版当年[2019版] 5.506 出版当年五年平均 4.232 出版前一年[2018版] 6.745 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

通讯作者：

通讯机构： [1]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China [2]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China [*1]Xuanwu Hospital of Capital Medical University, Beijing, China [*2]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

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