个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's disease in nonhuman primates.

| 认领 | 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Yue Feng[1,2] * ; Feng Su[3,4] * ; Lu Chunling[5] * ; Zhang Ting[3,6,7] * ; Tao Guoxian[5] ; Liu Jing[4] ; Yue Chunmei[3,8] ; Jing Naihe[3,4,9,10] ;
机构： [1]School of Biomedical Engineering, Hainan University, Haikou, 570228, China [2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China [3]State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences.University of Chinese Academy of Sciences, Shanghai, 200031, China [4]Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China [5]Wincon TheraCells Biotechnologies Co, LTD, Nanning, 530000, China [6]Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Ocular Fundus Diseases, Shanghai Engineering Center for Visual Science and Photomedicine, Shanghai, 200080, China [7]National Clinical Research Center for Ophthalmic Diseases, Shanghai, 200080, China [8]Department of Biological Sciences, School of Science, Xi’an Jiaotong-Liverpool University, Suzhou, 215000, China [9]CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China [10]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China
出处：
DOI： 10.1016/j.isci.2021.103207
ISSN：

摘要：
As an insidious and slowly progressive neurodegenerative disorder, Alzheimer's disease (AD) uniquely develops in humans but fails in other species. Therefore, it has been challenged to rebuild human AD in animals, including in non-human primates. Here, we bilaterally delivered synthetic Aβ oligomers (AβOs) into the cerebral parenchyma of cynomolgus monkeys, which rapidly drove the formation of massive Aβ plaques and concomitant neurofibrillary tangles in the cynomolgus brain. The amyloid and tau pathology as well as their co-occurrence in AβO-monkeys were reminiscent of those in patients with AD. In addition, the activated astrocytes and microglia surrounding Aβ plaques indicated the triggered neuroinflammation. The degenerative neurons and synapses around Aβ plaques also emerged in cynomolgus brain. Together, soluble AβOs caused the cascade of pathologic events associated with AD in monkeys as occurred in patients at the early phase, which could facilitate the development of a promising animal model for human AD in non-human primates.© 2021 The Authors.

基金：
National Key Basic Research and Development Program of China (2018YFA0108500, 2019YFA0801402, 2018YFA0800100, 2018YFA0108000, 2018YFA0107200, 2017YFA0102700), "Strategic Priority Research Program" of the Chinese Academy of Sciences, Grant No. (XDA16020501, XDA16020404), National Natural Science Foundation of China (81671224, 31472056, 31630043), and the Research Start-up Fund of Hainan University (RZ2100003016, RZ2000009939).

基金编号： 2018YFA0108500,2019YFA0801402,2018YFA0800100,2018YFA0108000,2018YFA0107200,2017YFA0102700 XDA16020501,XDA16020404 81671224,31472056,31630043 RZ2100003016,RZ2000009939

语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2020]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
最新[2025]版：
大类 | 2 区 综合性期刊
小类 | 2 区 综合性期刊
JCR分区：
出版当年[2019]版：
Q1 MULTIDISCIPLINARY SCIENCES
最新[2023]版：
Q1 MULTIDISCIPLINARY SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2019版] 出版当年五年平均 出版前一年[2018版] 出版后一年[2020版]

第一作者：
第一作者机构： [1]School of Biomedical Engineering, Hainan University, Haikou, 570228, China [2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China
共同第一作者：
通讯作者：
通讯机构： [1]School of Biomedical Engineering, Hainan University, Haikou, 570228, China [2]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China [3]State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences.University of Chinese Academy of Sciences, Shanghai, 200031, China [4]Bioland Laboratory (Guangzhou Regenerative Medicine and Health Guangdong Laboratory), Guangzhou, 510005, China [8]Department of Biological Sciences, School of Science, Xi’an Jiaotong-Liverpool University, Suzhou, 215000, China [9]CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China [10]Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China
推荐引用方式(GB/T 7714)：
Yue Feng,Feng Su,Lu Chunling,et al.Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's disease in nonhuman primates.[J].ISCIENCE.2021,24(9):doi:10.1016/j.isci.2021.103207.
APA：
Yue Feng,Feng Su,Lu Chunling,Zhang Ting,Tao Guoxian...&Jing Naihe.(2021).Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's disease in nonhuman primates..ISCIENCE,24,(9)
MLA：
Yue Feng,et al."Synthetic amyloid-β oligomers drive early pathological progression of Alzheimer's disease in nonhuman primates.".ISCIENCE 24..9(2021)

资源点击量：17236 今日访问量：0 总访问量：925 更新日期：2025-05-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院