详情页 - 首都医科大学宣武医院知识库

当前位置：首页 > 详情页

Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer's disease.

100| 认领 | 导出 | 链接全文 |

文献详情

资源类型：

WOS体系：

Pubmed体系：

收录情况： ◇ SCIE

作者：

机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University,Beijing 100053, China [2]Department of Pathology, The Affiliated Hospital ofWeifang Medical University, Weifang 261053, China [3]School of Life Scienceand Technology, Harbin Institute of Technology, Harbin 150080, China [4]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry ofScience and Technology, Collaborative Innovation Center for Brain Disorders,Capital Medical University, Beijing 100069, China [5]Academy for AdvancedInterdisciplinary Studies, Peking University, Beijing 100871, China [6]ChineseInstitute for Brain Research, Beijing 102206, China [7]School of Medicine,School of Pharmaceutical Sciences, THU-PKU Center for Life Sciences,Tsinghua University, Beijing 100091, China [8]Department of Anesthesiology,The Affiliated Hospital of Weifang Medical University, Weifang 261053, China [9]National Engineering Laboratory of Internet Medical Diagnosis andTreatment Technology, Xuanwu Hospital, Capital Medical University, Beijing100053, China [10]Beijing Key Laboratory of Hypoxia Translational Medicine,Xuanwu Hospital, Capital Medical University, Beijing 100053, China

出处：

DOI：

ISSN：

关键词： Alzheimer’s disease Vitamin C Genome-wide association study Mendelian randomization Inversevariance weighted

摘要：

Until now, observational studies have explored the impact of vitamin C intake on Alzheimer's disease (AD) risk, however, reported ambiguous findings. To develop effective therapies or prevention, the causal link between vitamin C levels and AD should be established.Here, we selected 11 plasma vitamin C genetic variants from a large-scale plasma vitamin C GWAS dataset (N = 52,018) as the potential instrumental variables. We extracted their corresponding summary statistics from large-scale IGAP clinically diagnosed AD GWAS dataset (N = 63,926) and UK Biobank AD proxy phenotype GWAS dataset (N = 314,278), as well as two UK Biobank subgroups including the maternal AD group (27,696 cases of maternal AD and 260,980 controls) and paternal AD group (14,338 cases of paternal AD and 245,941 controls). We then performed a Mendelian randomization (MR) study to evaluate the causal association between plasma vitamin C levels and the risk of AD and AD proxy phenotype. Meanwhile, we further verified these findings using a large-scale cognitive performance GWAS dataset (N = 257,841).In IGAP, we found no significant causal association between plasma vitamin C levels and the risk of AD. In UK Biobank, we found that per 1 SD increase in plasma vitamin C levels (about 20.2 μmol/l) was significantly associated with the reduced risk of AD proxy phenotype (OR = 0.93, 95% CI 0.88-0.98, P = 7.00E-03). A subgroup MR analysis in UK Biobank indicated that per 1 SD increase in plasma vitamin C levels could significantly reduce the risk of AD proxy phenotype in the maternal AD group (OR = 0.89, 95% CI 0.84-0.94, P = 7.29E-05), but not in the paternal AD group (OR = 1.02, 95% CI 0.92-1.12, P = 7.59E-01). The leave-one-out permutation further showed that the SLC23A1 rs33972313 variant largely changed the precision of the overall MR estimates in all these four GWAS datasets. Meanwhile, we did not observe any significant causal effect of plasma vitamin C levels on the cognitive performance.We demonstrated that there may be no causal association between plasma vitamin C levels and the risk of AD in people of European descent. The insistent findings in clinically diagnosed AD and AD proxy phenotype may be caused by the phenotypic heterogeneity.© 2021. The Author(s).

基金：

基金编号： 82071212,and81901181 12026414 2020A15 SML20150802 2019QL016,.2019PT007

语种：

被引次数：

WOS：

PubmedID：

中科院(CAS)分区：

出版当年[2020]版：

大类 | 3 区生物

小类 | 3 区遗传学 3 区营养学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区遗传学 4 区营养学

JCR分区：

出版当年[2019]版：

Q1 GENETICS & HEREDITY Q1 NUTRITION & DIETETICS

最新[2023]版：

Q2 GENETICS & HEREDITY Q2 NUTRITION & DIETETICS

影响因子： 3.3 最新[2023版] 3.8 最新五年平均 4.258 出版当年[2019版] 3.235 出版当年五年平均 2.883 出版前一年[2018版] 5.523 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University,Beijing 100053, China

通讯作者：

通讯机构： [4]Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry ofScience and Technology, Collaborative Innovation Center for Brain Disorders,Capital Medical University, Beijing 100069, China [6]ChineseInstitute for Brain Research, Beijing 102206, China [9]National Engineering Laboratory of Internet Medical Diagnosis andTreatment Technology, Xuanwu Hospital, Capital Medical University, Beijing100053, China [10]Beijing Key Laboratory of Hypoxia Translational Medicine,Xuanwu Hospital, Capital Medical University, Beijing 100053, China

推荐引用方式(GB/T 7714)：

APA：

MLA：

Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer's disease.

文献详情

相关文献