机构：[1]Department of Nephrology, Peking University Third Hospital, Beijing, China[2]Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China[3]Department of Nephrology, Xuanwu Hospital Capital Medical University, Beijing, China内科系统肾科首都医科大学宣武医院
Background Fatty acid binding protein 4 (FABP4) is an adipokine that was mainly derived from adipocytes and macrophages. Vascular calcification (VC) is highly prevalent in peritoneal dialysis (PD) patients and could predict their cardiovascular mortality. The pathogenesis of VC is complex, and adipokines may play an important role in it. This study aimed to examine the relationship between serum FABP4 and VC in PD patients. Methods Serum FABP4 was measured by enzyme-linked immunosorbent assay. According to the median value of serum FABP4, the participants were divided into the low FABP4 group and the high FABP4 group. Lateral plain X-ray films of abdomen were used to evaluate the abdominal aortic calcification (AAC) score. The participants were divided into the high AAC score group (AAC score >= 4, indicating moderate or heavy VC) and the low AAC score group (AAC score <4, indicating no or mild VC). Results 116 PD patients were involved in the study. The AAC score and the proportion of patients with an AAC score >= 4 of the high FABP4 group were significantly higher than those of the low FABP4 group. Serum FABP4 of the high AAC score group was significantly higher than that of the low AAC score group [164.5 (138.4, 362.8) ng/mL versus 144.7 (123.8, 170.1) ng/mL, p = 0.002]. Serum FABP4 was positively associated with the AAC score according to the multivariate linear regression analysis. In the multivariate logistic regression analysis, serum FABP4 was the independent influencer of an AAC score >= 4. Conclusions Serum FABP4 is positively associated with the AAC score and is an independent marker of AAC in PD patients.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873619, 81570663]; Key Clinical Program of Peking University Third Hospital [BYSYZD2019039]; PKU-Baidu Fund [2020BD030]; China International Medical Foundation [Z-2017-24-2037]
第一作者机构：[1]Department of Nephrology, Peking University Third Hospital, Beijing, China
通讯作者：
通讯机构：[1]Department of Nephrology, Peking University Third Hospital, Beijing, China[3]Department of Nephrology, Xuanwu Hospital Capital Medical University, Beijing, China[*1]Department of Nephrology, Xuanwu Hospital Capital Medical University, 45 Changchun Road, Xicheng District, 100053 Beijing, China[*2]Department of Nephrology, Peking University Third Hospital, 49 North Garden Rd, Haidian District, 100191 Beijing, China.
推荐引用方式(GB/T 7714)：
Zhou Sijia,Wang Xiaoxiao,Shi Junbao,et al.Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients[J].RENAL FAILURE.2021,43(1):1539-1548.doi:10.1080/0886022X.2021.2003205.
APA：
Zhou, Sijia,Wang, Xiaoxiao,Shi, Junbao,Han, Qingfeng,He, Lian...&Zhang, Aihua.(2021).Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients.RENAL FAILURE,43,(1)
MLA：
Zhou, Sijia,et al."Serum fatty acid binding protein 4 levels are associated with abdominal aortic calcification in peritoneal dialysis patients".RENAL FAILURE 43..1(2021):1539-1548
