机构：[1]Department of Neurology, Geriatrics and Neurobiology, National Clinical Research Center of Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China神经科系统内科系统神经内科老年医学科首都医科大学宣武医院神经生物学研究室科技平台神经变性病教育部重点实验室科技平台[2]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing Institute of Geriatrics, Beijing, China[3]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China[4]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
Sarcopenia is a new type of senile syndrome with progressive skeletal muscle mass loss with age, accompanied by decreased muscle strength and/or muscle function. Sarcopenia poses a serious threat to the health of the elderly and increases the burden of family and society. The underlying pathophysiological mechanisms of sarcopenia are still unclear. Recent studies have shown that changes of skeletal muscle metabolism are the risk factors for sarcopenia. Furthermore, the importance of the skeletal muscle metabolic microenvironment in regulating satellite cells (SCs) is gaining significant attention. Skeletal muscle metabolism has intrinsic relationship with the regulation of skeletal muscle mass and regeneration. This review is to discuss recent findings regarding skeletal muscle metabolic alternation and the development of sarcopenia, hoping to contribute better understanding and treatment of sarcopenia.
基金：
Key Realm R&D Program of Guangdong Province [2018B030337001]; Advanced Innovation Center for Human Brain Protection; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M641416]; Beijing Postdoctoral Research FoundationChina Postdoctoral Science Foundation [zz2019-14]; National Key R&D Program of China [2018YFC1312001, 2017YFC0840105, 2017ZX0930 4018]; National Natural Science Foundation of China Youth Project [82101657]
第一作者机构：[1]Department of Neurology, Geriatrics and Neurobiology, National Clinical Research Center of Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China[4]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Neurology, Geriatrics and Neurobiology, National Clinical Research Center of Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing, China[2]Clinical Center for Parkinson’s Disease, Capital Medical University, Beijing Institute of Geriatrics, Beijing, China[3]Key Laboratory for Neurodegenerative Disease of the Ministry of Education, Beijing Key Laboratory for Parkinson’s Disease, Beijing Institute of Brain Disorders, Collaborative Innovation Center for Brain Disorders, Capital Medical University, Beijing, China[4]Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China[*1]Department of Neurobiology, Xuanwu Hospital of Capital Medical University, 45 Changchun Road, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Yang Qiumei,Chan Piu.Skeletal Muscle Metabolic Alternation Develops Sarcopenia[J].AGING AND DISEASE.2022,13(3):801-814.doi:10.14336/AD.2021.1107.
APA：
Yang, Qiumei&Chan, Piu.(2022).Skeletal Muscle Metabolic Alternation Develops Sarcopenia.AGING AND DISEASE,13,(3)
