机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China神经科系统神经内科首都医科大学宣武医院[2]Department of Neurology, Beijing Sixth Hospital, Beijing 100007, China[3]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China[4]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院[5]Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China外科系统眼科首都医科大学宣武医院[6]Banner Alzheimer’s Institute, Phoenix, AZ, USA[7]National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing 100053, China
Simultanagnosia is a common symptom of posterior cortical atrophy, and its association with brain structural and functional changes remains unclear. In our study, 18 posterior cortical atrophy patients with simultanagnosia, 29 patients with Alzheimer's disease and 20 cognitively normal controls were recruited and subjected to full neuropsychological evaluation, including simultanagnosia tests, and structural and resting-state functional MRI. The gray matter volume was assessed by voxel-based morphometry, while the intrinsic functional connectivity was evaluated using the reduced gray matter volume regions of interest as the seed. In contrast to the patients with Alzheimer's disease, those with posterior cortical atrophy showed the following: (1) markedly lower simultanagnosia test scores, (2) an altered regional gray matter volume of the left middle occipital gyrus and ventral occipital areas, and (3) lowered intrinsic functional connectivity with the left middle occipital gyrus, left lingual gyrus and right middle occipital gyrus separately. Additionally, the gray matter volume of the left middle occipital gyrus and left inferior occipital gyrus were each correlated with simultanagnosia in posterior cortical atrophy patients. The intrinsic functional connectivity of the left middle occipital gyrus with the right superior occipital gyrus and that of the right middle occipital gyrus with the left superior parietal gyrus were also correlated with simultanagnosia in posterior cortical atrophy patients. In summary, this study indicated that simultanagnosia is associated with gray matter reductions and decreased functional connectivity in the left middle occipital gyrus and the left inferior occipital gyrus in patients with posterior cortical atrophy.
基金：
Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2019YFC0118600]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470074, 81971011]; Beijing Municipal Science and Technology Committee [D171100008217005, 7202060]; Beijing Municipal Government [PXM2017_026283_000002]
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China[7]National Clinical Research Center for Geriatric Disorders, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Cui Yue,Liu Yang,Yang Caishui,et al.Brain structural and functional anomalies associated with simultanagnosia in patients with posterior cortical atrophy[J].BRAIN IMAGING AND BEHAVIOR.2022,16(3):1148-1162.doi:10.1007/s11682-021-00568-8.
APA：
Cui, Yue,Liu, Yang,Yang, Caishui,Cui, Chunlei,Jing, Donglai...&Wu, Liyong.(2022).Brain structural and functional anomalies associated with simultanagnosia in patients with posterior cortical atrophy.BRAIN IMAGING AND BEHAVIOR,16,(3)
MLA：
Cui, Yue,et al."Brain structural and functional anomalies associated with simultanagnosia in patients with posterior cortical atrophy".BRAIN IMAGING AND BEHAVIOR 16..3(2022):1148-1162
