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The role of hypoxia in stem cell regulation of the central nervous system: From embryonic development to adult proliferation.

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机构： [1]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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关键词： dentate gyrus hypoxia neurogenesis stem cell subventricular zone

摘要：

Hypoxia is involved in the regulation of various cell functions in the body, including the regulation of stem cells. The hypoxic microenvironment is indispensable from embryonic development to the regeneration and repair of adult cells. In addition to embryonic stem cells, which need to maintain their self-renewal properties and pluripotency in a hypoxic environment, adult stem cells, including neural stem cells (NSCs), also exist in a hypoxic microenvironment. The subventricular zone (SVZ) and hippocampal dentate gyrus (DG) are the main sites of adult neurogenesis in the brain. Hypoxia can promote the proliferation, migration, and maturation of NSCs in these regions. Also, because most neurons in the brain are non-regenerative, stem cell transplantation is considered as a promising strategy for treating central nervous system (CNS) diseases. Hypoxic treatment also increases the effectiveness of stem cell therapy. In this review, we firstly describe the role of hypoxia in different stem cells, such as embryonic stem cells, NSCs, and induced pluripotent stem cells, and discuss the role of hypoxia-treated stem cells in CNS diseases treatment. Furthermore, we highlight the role and mechanisms of hypoxia in regulating adult neurogenesis in the SVZ and DG and adult proliferation of other cells in the CNS.© 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区神经科学 2 区药学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

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出版当年[2019]版：

Q1 PHARMACOLOGY & PHARMACY Q2 NEUROSCIENCES

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY Q1 NEUROSCIENCES

影响因子： 4.8 最新[2023版] 5.9 最新五年平均 4.074 出版当年[2019版] 3.873 出版当年五年平均 3.394 出版前一年[2018版] 5.243 出版后一年[2020版]

第一作者：

第一作者机构： [1]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China

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通讯作者：

通讯机构： [1]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China [2]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Beijing Institute of Brain Disorders, Capital Medical University, 10 Xi Tou Tiao, You Anmen, Beijing 100069, China.

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