Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies
机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China,神经科系统神经外科首都医科大学宣武医院[2]Department of Neurosurgery, ChinaInternational Neuroscience Institute, Beijing, China,[3]Department of Neurosurgery, National Clinical Research Center for GeriatricDiseases, Beijing, China,[4]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing,China,医技科室放射科首都医科大学宣武医院[5]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China,[6]Department of NuclearMedicine, The Affiliated Hospital of Qingdao University, Qingdao, China,[7]Department of Pathology, Xuanwu Hospital, CapitalMedical University, Beijing, China,医技科室病理科首都医科大学宣武医院[8]Department of Medicine, Nanjing Geneseeq Technology Inc., Nanjing, China
Gliomas exhibit high intra-tumoral histological and molecular heterogeneity. Introducing stereotactic biopsy, we achieved a superior molecular analysis of glioma using O-(2-18F-fluoroethyl)-L-tyrosine (FET)-positron emission tomography (PET) and diffusion-weighted magnetic resonance imaging (DWI). Patients underwent simultaneous DWI and FET-PET scans. Correlations between biopsy-derived tumor tissue values, such as the tumor-to-background ratio (TBR) and apparent diffusion coefficient (ADC)/exponential ADC (eADC) and histopathological diagnoses and those between relevant genes and TBR and ADC values were determined. Tumor regions with human telomerase reverse transcriptase (hTERT) mutation had higher TBR and lower ADC values. Tumor protein P53 mutation correlated with lower TBR and higher ADC values. alpha-thalassemia/mental-retardation-syndrome-X-linked gene (ATRX) correlated with higher ADC values. 1p/19q codeletion and epidermal growth factor receptor (EGFR) mutations correlated with lower ADC values. Isocitrate dehydrogenase 1 (IDH1) mutations correlated with higher TBRmean values. No correlation existed between TBRmax/TBRmean/ADC/eADC values and phosphatase and tensin homolog mutations (PTEN) or O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation. Furthermore, TBR/ADC combination had a higher diagnostic accuracy than each single imaging method for high-grade and IDH1-, hTERT-, and EGFR-mutated gliomas. This is the first study establishing the accurate diagnostic criteria for glioma based on FET-PET and DWI.
基金：
This work was funded by the Youth Program of National Natural
Science Foundation of China (81802485 to YC), Beijing New-star
Plan of Science and Technology (Z201100006820148 to YC).
Beijing Municipal Administration of Hospitals’ Ascent Plan
(DFL20180802 to JL).
第一作者机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Department of Neurosurgery, ChinaInternational Neuroscience Institute, Beijing, China,[3]Department of Neurosurgery, National Clinical Research Center for GeriatricDiseases, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Department of Neurosurgery, ChinaInternational Neuroscience Institute, Beijing, China,[4]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing,China,[5]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China,
推荐引用方式(GB/T 7714)：
Cheng Ye,Song Shuangshuang,Wei Yukui,et al.Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies[J].FRONTIERS IN ONCOLOGY.2021,11:doi:10.3389/fonc.2021.743655.
APA：
Cheng, Ye,Song, Shuangshuang,Wei, Yukui,Xu, Geng,An, Yang...&Lin, Qingtang.(2021).Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies.FRONTIERS IN ONCOLOGY,11,
MLA：
Cheng, Ye,et al."Glioma Imaging by O-(2-18F-Fluoroethyl)-L-Tyrosine PET and Diffusion-Weighted MRI and Correlation With Molecular Phenotypes, Validated by PET/MR-Guided Biopsies".FRONTIERS IN ONCOLOGY 11.(2021)
