机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[2]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China[3]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China医技科室放射科首都医科大学宣武医院[4]National Clinical Research Center for Geriatric Disorders, Beijing, China[5]Department of Psychiatry and Psychotherapy, University of Cologne, Medical Faculty, Cologne, Germany[6]Department of Psychiatry, University of Cambridge, United Kingdom[7]Sino-Britain Centre for Cognition and Ageing Research, Southwest University, Chongqing, China[8]German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany[9]Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Germany[10]Turku PET Centre, Turku, Finland[11]Athinlula A.Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA[12]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China[13]School of Biomedical Engineering, Hainan University, Haikou, China
Subjective cognitive decline (SCD), an at-risk condition of Alzheimer's disease (AD), can involve various cognitive domains, such as memory, language, planning, and attention.We aims to explore the differences in amyloid load between the single memory domain SCD (sd-SCD) and the multidomain SCD (md-SCD) and assess the relationship of amyloid pathology with quantitative SCD scores and objective cognition.A total of 63 SCD participants from the SILCODE study underwent the clinical evaluation, neuropsychological assessment, and 18F-florbetapir PET scan. Global amyloid standard uptake value ratio (SUVr) was calculated. Additionally, regional amyloid SUVr was quantified in 12 brain regions of interests. A nonparametric rank ANCOVA was used to compare the global and regional amyloid SUVr between the md-SCD (n = 34) and sd-SCD (n = 29) groups. A multiple linear regression analysis was conducted to test the relationship of amyloid SUVr with quantitative SCD scores and objective cognition.Compared with individuals with sd-SCD, individuals with md-SCD had increased global amyloid SUVr (F = 5.033, p = 0.029) and regional amyloid SUVr in the left middle temporal gyrus (F = 12.309, p = 0.001; Bonferroni corrected), after controlling for the effects of age, sex, and education. When pooling all SCD participants together, the increased global amyloid SUVr was related with higher SCD-plus sum scores and lower Auditory Verbal Learning Test-delayed recall scores.According to our findings, individuals with md-SCD showed higher amyloid accumulation than individuals with sd-SCD, suggesting that md-SCD may experience a more advanced stage of SCD. Additionally, increased global amyloid load was predictive of a poorer episodic memory function in SCD individuals.
第一作者机构：[1]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Xiaoqi Wang,Qiuhui Bi,Jie Lu,et al.Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE.[J].JOURNAL OF ALZHEIMERS DISEASE.2022,85(4):1573-1582.doi:10.3233/JAD-215373.
APA：
Xiaoqi Wang,Qiuhui Bi,Jie Lu,Piu Chan,Xiaochen Hu...&Ying Han.(2022).Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE..JOURNAL OF ALZHEIMERS DISEASE,85,(4)
MLA：
Xiaoqi Wang,et al."Difference in Amyloid Load Between Single Memory Domain and Multidomain Subjective Cognitive Decline: A Study from the SILCODE.".JOURNAL OF ALZHEIMERS DISEASE 85..4(2022):1573-1582
