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Pathogeneses and Imaging Features of Cerebral White Matter Lesions of Vascular Origins.

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机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China [4]Division of Clinical Neuroscience,Queen's Medical Center School of Medicine, the University of Nottingham, Nottingham NG7 2UH, UK [5]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, Michigan 48201, USA

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关键词： cerebral white matter lesion neuroimaging pathomechanism cerebral vascular disease

摘要：

White matter lesion (WML), also known as white matter hyperintensities or leukoaraiosis, was first termed in 1986 to describe the hyperintense signals on T2-weighted imaging (T2WI) and fluid-attenuated inversion recovery (FLAIR) maps. Over the past decades, a growing body of pathophysiological findings regarding WMLs have been discovered and discussed. Currently, the generally accepted WML pathogeneses mainly include hypoxia-ischemia, endothelial dysfunction, blood-brain barrier disruption, and infiltration of inflammatory mediators or cytokines. However, none of them can explain the whole dynamics of WML formation. Herein, we primarily focus on the pathogeneses and neuroimaging features of vascular WMLs. To achieve this goal, we searched papers with any type published in PubMed from 1950 to 2020 and cross-referenced the keywords including "leukoencephalopathy", "leukoaraiosis", "white matter hyperintensity", "white matter lesion", "pathogenesis", "pathology", "pathophysiology", and "neuroimaging". Moreover, references of the selected articles were browsed and searched for additional pertinent articles. We believe this work will supply the robust references for clinicians to further understand the different WML patterns of varying vascular etiologies and thus make customized treatment.Copyright: © 2021 Wu et al.

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出版当年[2020]版：

大类 | 2 区医学

小类 | 2 区老年医学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区老年医学

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出版当年[2019]版：

Q1 GERIATRICS & GERONTOLOGY

最新[2023]版：

Q1 GERIATRICS & GERONTOLOGY

影响因子： 7 最新[2023版] 7.1 最新五年平均 5.402 出版当年[2019版] 5.506 出版当年五年平均 4.232 出版前一年[2018版] 6.745 出版后一年[2020版]

第一作者：

第一作者机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China

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通讯作者：

通讯机构： [1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [2]Advanced Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China [3]Department of China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

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