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Endovascular Therapy for Symptomatic Intracranial Artery Stenosis: a Systematic Review and Network Meta-analysis

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机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, 45 Changchun Ave, Beijing, Peoples R China [2]China Int Neurosci Inst China INI, Beijing 100053, Peoples R China [3]Capital Med Univ, Xuanwu Hosp, Dept Evidence Based Med, Beijing, Peoples R China [4]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China [5]Capital Med Univ, Xuanwu Hosp, Med Lib, Beijing, Peoples R China [6]Imperial Coll London, Natl Heart & Lung Inst, London, England [7]Municipal Key Lab Clin Epidemiol, Beijing 100053, Peoples R China [8]Capital Med Univ, Xuanwu Hosp, Dept Intervent Neuroradiol, 45 Changchun St, Beijing, Peoples R China
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关键词: Angioplasty and stenting Intracranial stenosis Network meta-analysis Endovascular therapy

摘要:
Intracranial artery atherosclerotic stenosis (ICAS) is one of the most common causes of stroke. Endovascular therapy including balloon angioplasty alone (BA), balloon-mounted stent (BMS), or self-expanding stent (SES) was an important alternative to treat symptomatic ICAS refractory to medical treatment, while none of the three subtypes has been established to be the primary option. We conducted a systematic review and network meta-analysis to determine both the safety and efficacy and establish a hierarchy of different endovascular therapies on symptomatic ICAS. Major databases including MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched for studies comparing outcomes of three different endovascular approaches and other comparable non-endovascular therapies for symptomatic ICAS patients published from 1 January 2000 to 1 November 2021. Primary outcomes included short-term mortality or stroke rate (peri-procedural, or mean follow-up <= 3 months), and long-term mortality or stroke rate (mean follow-up >= 6 months). Pairwise and network meta-analyses based on the above systematic review were conducted. A total of 19 eligible studies involving 3386 patients treated with 4 different approaches (BA, SES, BMS, and medical treatment) were analyzed. For primary outcome, BA had the highest ranking (SUCRA value 78), followed by BMS (SUCRA value 21.5) and SES (SUCRA value 13.1). The short-term mortality or stroke rate was significantly lower in the BA group compared to SES (OR = 2.50; 95% CI 1.12 to 5.57; p = 0.026) or BMS (OR = 0.43; 95% CI 0.19 to 0.96; p = 0.038). Other primary and secondary outcomes were no different among all three types of endovascular therapy. Overall, the studies were of good methodological quality and the consistency was acceptable across all network meta-analyses. BA offers the highest level of safety outcomes in terms of short-term mortality or stroke in treating symptomatic patients with intracranial artery stenosis, compared to SES and BMS, which needs to be confirmed in future studies.

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基金编号: Z201100005520019

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出版当年[2021]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 临床神经病学 2 区 神经科学
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出版当年[2020]版:
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES
最新[2023]版:
Q1 CLINICAL NEUROLOGY Q2 NEUROSCIENCES

影响因子: 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

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第一作者机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, 45 Changchun Ave, Beijing, Peoples R China [2]China Int Neurosci Inst China INI, Beijing 100053, Peoples R China
通讯作者:
通讯机构: [1]Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, 45 Changchun Ave, Beijing, Peoples R China [2]China Int Neurosci Inst China INI, Beijing 100053, Peoples R China [4]Capital Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing, Peoples R China [7]Municipal Key Lab Clin Epidemiol, Beijing 100053, Peoples R China [8]Capital Med Univ, Xuanwu Hosp, Dept Intervent Neuroradiol, 45 Changchun St, Beijing, Peoples R China
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