个人科研网厅 | | 帮助
首都医科大学宣武医院知识库
高级检索
当前位置： 首页 > 详情页

MGMT promoter methylation status shows no effect on [18F]FET uptake and CBF in gliomas: a stereotactic image-based histological validation study.

| 导出 | |

文献详情

资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Song Shuangshuang[1,2,3] * ; Shan Yi[1,3] ; Wang Leiming[4] ; Cheng Ye[5] ; Yang Hongwei[1,3] ; Zhao Guoguang[5] ; Wang Zhenguang[2] ; Lu Jie[1,3] ;
机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, 100053 Beijing, People’s Republic of China [2]Department of NuclearMedicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China [3]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China [4]Department of Pathology, Xuanwu Hospital, Capital Medical University, Beijing, China [5]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1007/s00330-022-08606-9
ISSN：

摘要：
To investigate the effects of O6-methylguanine DNA methyltransferase (MGMT) promoter methylation status of gliomas on O-(2-18F-fluoroethyl)-L-tyrosine ([18F]FET) uptake and cerebral blood flow (CBF) of arterial spin labeling (ASL), evaluated by hybrid PET/MR. Stereotactic biopsy was used to validate the findings.A set of whole tumor and reference volumes of interest (VOIs) based on PET/FLAIR imaging were delineated and transferred to the corresponding [18F]FET PET and CBF maps in 57 patients with newly diagnosed gliomas. The mean and max tumor-to-brain ratio (TBR) and normalized CBF (nCBF) were calculated. The predictive efficacy of [18F]FET PET and CBF in determining MGMT promoter methylation status of glioma were evaluated by whole tumor analysis and stereotactic biopsy. The correlation between PET/MR parameters and MGMT promoter methylation were analyzed using histological specimens acquired from multiple stereotactic biopsies.Based on the analysis of whole tumor volume and biopsy site, TBRmean, TBRmax, nCBFmean, and nCBFmax showed no statistically significant differences between gliomas with and without MGMT promoter methylation (all p > 0.05). Furthermore, stereotactic biopsy demonstrated that TBRmean, TBRmax, nCBFmean, and nCBFmax showed no correlation with MGMT promoter methylation (r = -0.117, p = 0.579; r = -0.161, p = 0.443; r = -0.271, p = 0.191; r = -0.300, p = 0.145; respectively).MGMT promoter methylation status shows no effect on [18F]FET uptake and CBF of ASL in gliomas. Stereotactic biopsy validates it and further reveals there is no correlation of [18F]FET PET uptake and CBF with the percentages of MGMT promoter methylation.• Based on whole tumor VOI assessment, MGMT promoter methylation status shows no effect on [18F]FET uptake and CBF of ASL in gliomas. • For WHO grade IV glioblastomas, [18F]FET PET and ASL parameters based on hybrid PET/MR fail to predict the MGMT promoter methylation status. • Stereotactic image-based histology reveals that there is no correlation of [18F]FET PET uptake and CBF with the status and percentages of MGMT promoter methylation in gliomas.© 2022. The Author(s), under exclusive licence to European Society of Radiology.

基金：
This study has received funding from the Beijing Municipal Administration of Hospitals’ Ascent Plan (DFL20180802).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 核医学
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 核医学
JCR分区：
出版当年[2020]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2023]版：
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, 100053 Beijing, People’s Republic of China [2]Department of NuclearMedicine, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China [3]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China
通讯作者：
通讯机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, 100053 Beijing, People’s Republic of China [3]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Song Shuangshuang,Shan Yi,Wang Leiming,et al.MGMT promoter methylation status shows no effect on [18F]FET uptake and CBF in gliomas: a stereotactic image-based histological validation study.[J].EUROPEAN RADIOLOGY.2022,32(8):5577-5587.doi:10.1007/s00330-022-08606-9.
APA：
Song Shuangshuang,Shan Yi,Wang Leiming,Cheng Ye,Yang Hongwei...&Lu Jie.(2022).MGMT promoter methylation status shows no effect on [18F]FET uptake and CBF in gliomas: a stereotactic image-based histological validation study..EUROPEAN RADIOLOGY,32,(8)
MLA：
Song Shuangshuang,et al."MGMT promoter methylation status shows no effect on [18F]FET uptake and CBF in gliomas: a stereotactic image-based histological validation study.".EUROPEAN RADIOLOGY 32..8(2022):5577-5587

资源点击量：16409 今日访问量：0 总访问量：869 更新日期：2025-01-01 建议使用谷歌、火狐浏览器 常见问题

版权所有©2020 首都医科大学宣武医院 技术支持：重庆聚合科技有限公司 地址：北京市西城区长椿街45号宣武医院