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Generation and characterization of a human induced pluripotent stem cell line (XWHNi001-A) derived from an Alzheimer's disease patient with mutation in the APP gene.

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收录情况： ◇ SCIE

作者：

机构： [1]Innovation Center for Neurological Disorders, Xuan Wu Hospital, Capital Medical University, China [2]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China [3]School of Biological Science and Medical Engineering, Beihang University, Beijing, China [4]Beijing Geriatric Hospital, Beijing, China [5]College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China

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摘要：

Mutations in the APP gene are popularly known as the second cause trigger the familial Alzheimer's disease (AD). We generated a human induced pluripotent stem cell (iPSC) line from the peripheral blood mononuclear cells isolated from an AD patient using non-integrative Sendai virus. The iPSC line highly expresses pluripotency markers, has the capacity to differentiate into the normal teratoma tissue, retains the APP mutation, and displays the normal karyotype. The iPSC line will provide a useful resource to study the pathogenesis and drugs screening of AD.Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.

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出版当年[2021]版：

大类 | 4 区医学

小类 | 4 区细胞与组织工程 4 区生物工程与应用微生物 4 区细胞生物学

最新[2023]版：

大类 | 4 区医学

小类 | 4 区生物工程与应用微生物 4 区细胞与组织工程 4 区细胞生物学

JCR分区：

出版当年[2020]版：

Q4 CELL BIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

最新[2023]版：

Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY

影响因子： 0.8 最新[2023版] 1.1 最新五年平均 2.02 出版当年[2020版] 2.523 出版当年五年平均 4.495 出版前一年[2019版] 1.587 出版后一年[2021版]

第一作者：

第一作者机构： [1]Innovation Center for Neurological Disorders, Xuan Wu Hospital, Capital Medical University, China [2]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China [*1]Innovation center for neurological disorders & Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.

通讯作者：

通讯机构： [1]Innovation Center for Neurological Disorders, Xuan Wu Hospital, Capital Medical University, China [2]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China [*1]Innovation center for neurological disorders & Department of Neurology, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.

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