机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing 100053, China 神经科系统神经内科首都医科大学宣武医院[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100069, China [3]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China [4]Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing 100053, China
出处：
ISSN：
摘要：
Although Alzheimer's disease (AD), as the most common dementia and the major cause for senile dementia, is usually characterized by cognitive impairments, neuropsychiatric symptoms affect most of patients with AD [1]. Neuropsychiatric symptoms are significantly associated with decreased quality of patients' life [2], the heavy burden on caregivers [3], rapid cognitive decline, increased risk of institutionalization, and low survival rate of patients with AD [4,5]. Sex difference is a common phenomenon in AD and manifests in many ways, and some previous studies had suggested sex-specific neuropsychiatric symptoms in AD. It was reported that male patients with AD were more frequently to exhibit apathy and anxiety, while delusion was more common in female patients [6-8]. The sex differences in neuropsychiatric symptoms also influence the decision of treatment, and male patients are more likely to receive antipsychotic medications [9],
基金：
This paper was supported by the Specialized Research
Fund for the Doctoral Program of Higher Education
(20131107120002), CHINA-CANADA Joint Initiative on
Alzheimer’s Disease and Related Disorders (81261120571),
the National 973 Project Grant of China (2011CB504104),
Scientific Promoting Project of Beijing Institute for Brain
Disorders (BIBDPXM2014 014226 000016), Seed Grant
of International Alliance of Translational Neuroscience
(PXM2014 014226 000006), Key Medical Professional
Development Plan of Beijing Municipal Administration of
Hospitals (ZYLX201301), the National Science and Technology
Major Projects for “Major New Drug Innovation
and Development” of the Twelfth 5-Year Plan Period
(2011ZX09307-001-03), the National Key Technology
R&D Program in the Eleventh Five-Year Plan Period
(2006BAI02B01), the Key Project of the National Natural Science
Foundation of China (30830045), Beijing Municipal
Science & Technology Commission (Z151100004015078),
and Beijing Talents Fund (2014000021223ZK31).
语种：
外文
中科院(CAS)分区：
出版当年[2014]版：
大类|4 区医学
小类|4 区临床神经病学
最新[2023]版：
大类|4 区医学
小类|4 区临床神经病学
第一作者：
第一作者机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing 100053, China [2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100069, China [3]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China [4]Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Yi Xing,Yi Tang,Jianping Jia.Sex Differences in Neuropsychiatric Symptoms of Alzheimer's Disease: The Modifying Effect of Apolipoprotein ￡ e4 Status[J].Behavioural neurology.2015,(Pt.2):
APA：
Yi Xing,Yi Tang&Jianping Jia.(2015).Sex Differences in Neuropsychiatric Symptoms of Alzheimer's Disease: The Modifying Effect of Apolipoprotein ￡ e4 Status.Behavioural neurology,,(Pt.2)
MLA：
Yi Xing,et al."Sex Differences in Neuropsychiatric Symptoms of Alzheimer's Disease: The Modifying Effect of Apolipoprotein ￡ e4 Status".Behavioural neurology ..Pt.2(2015)
