机构：[1]National Institute of Biological Sciences, Beijing 102206, China.[2]Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.[3]State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.[4]Xuanwu Hospital, Capital Medical University, Beijing 100053, China.首都医科大学宣武医院
SignificanceDiabetic neuropathy is a commonly occurring complication of diabetes that affects hundreds of millions of patients worldwide. Patients suffering from diabetic neuropathy experience abnormal sensations and have damage in their peripheral nerve axons as well as myelin, a tightly packed Schwann cell sheath that wraps around axons to provide insulation and increases electrical conductivity along the nerve fibers. The molecular events underlying myelin damage in diabetic neuropathy are largely unknown, and there is no efficacious treatment for the disease. The current study, using a diabetic mouse model and human patient nerve samples, uncovered a molecular mechanism underlying myelin sheath damage in diabetic neuropathy and provides a potential treatment strategy for the disease.
基金：
Chinese Ministry of Science and Technology, the Beijing Municipal
Science and Technology Commission, the National Natural Science Foundation
of China (32100759), and the Chinese Universities Scientific Fund
(2021RC013).
第一作者机构：[1]National Institute of Biological Sciences, Beijing 102206, China.[2]Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
共同第一作者：
通讯作者：
通讯机构：[1]National Institute of Biological Sciences, Beijing 102206, China.[2]Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing 102206, China.
推荐引用方式(GB/T 7714)：
Guo Jia,Guo Zehui,Huang Yanju,et al.Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy.[J].PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.2022,119(14):doi:10.1073/pnas.2121552119.
APA：
Guo Jia,Guo Zehui,Huang Yanju,Ma Suchen,Yan Bo...&Ying Zhengxin.(2022).Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy..PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,119,(14)
MLA：
Guo Jia,et al."Blockage of MLKL prevents myelin damage in experimental diabetic neuropathy.".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 119..14(2022)
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