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Five Major Psychiatric Disorders and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.

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机构: [1]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical. [2]Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Perth, 8 Australia. [3]School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian China. [4]Neurodegenerative Laboratory of Ministry of Education of the Peoples Republic of China, Beijing, China.
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关键词: Alzheimer’s disease causality genetic association Mendelian randomization psychiatric disorders

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Extensive studies put forward the association between Alzheimer's disease (AD) and psychiatric disorders; however, it remains unclear whether these associations are causal.We aimed to assess the potential causal relationship between major psychiatric disorders and AD.A bidirectional two-sample Mendelian randomization (MR) was applied to evaluate potential causality between five psychiatric disorders and AD by selecting the single-nucleotide polymorphisms from the genome-wide association studies as instrumental variables. Inverse-variance weighted (IVW) method was used as the main analyzing approach to estimate possible causal effects, alternative methods including MR-Egger, the MR pleiotropy residual sum and outlier, and leave-one-out analysis method were implemented as sensitivity analyzing approaches to ensure the robustness of results.All forward and reverse MR analyses consistently suggested absent causal relations between psychiatric disorders and AD risk [forward IVW: ORADHD, 1.030, 95% CI, 0.908-1.168, p = 0.674; ORanxiety disorders, 0.904, 95% CI, 0.722-1.131, p = 0.377; ORASD, 0.973, 95% CI, 0.746-1.272, p = 0.846; ORBIP, 1.033, 95% CI, 0.925-1.153, p = 0.564; and ORschizophrenia, 1.039, 95% CI, 0.986-1.095, p = 0.156; reverse IVW: ORADHD, 0.993, 95% CI, 0.954-1.034, p = 0.746; ORanxiety disorders, 1.000, 95% CI, 0.999-1.000, p = 0.898; ORASD, 1.001, 95% CI, 0.962-1.042, p = 0.949; ORBIP, 0.997, 95% CI, 0.966-1.028, p = 0.831; and ORschizophrenia, 1.013, 95% CI, 0.978-1.051, p = 0.466].There is no significant evidence supporting the causal association between the five major psychiatric disorders and AD.

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出版当年[2021]版:
大类 | 3 区 医学
小类 | 4 区 神经科学
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大类 | 3 区 医学
小类 | 3 区 神经科学
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Q2 NEUROSCIENCES
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Q2 NEUROSCIENCES

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第一作者机构: [1]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical.
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通讯机构: [1]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical. [4]Neurodegenerative Laboratory of Ministry of Education of the Peoples Republic of China, Beijing, China. [*1]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China
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