机构:[1]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical.神经科系统神经内科首都医科大学宣武医院[2]Centre for Precision Health, School of Medical and Health Sciences, Edith Cowan University, Perth, 8 Australia.[3]School of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian China.[4]Neurodegenerative Laboratory of Ministry of Education of the Peoples Republic of China, Beijing, China.
Extensive studies put forward the association between Alzheimer's disease (AD) and psychiatric disorders; however, it remains unclear whether these associations are causal.We aimed to assess the potential causal relationship between major psychiatric disorders and AD.A bidirectional two-sample Mendelian randomization (MR) was applied to evaluate potential causality between five psychiatric disorders and AD by selecting the single-nucleotide polymorphisms from the genome-wide association studies as instrumental variables. Inverse-variance weighted (IVW) method was used as the main analyzing approach to estimate possible causal effects, alternative methods including MR-Egger, the MR pleiotropy residual sum and outlier, and leave-one-out analysis method were implemented as sensitivity analyzing approaches to ensure the robustness of results.All forward and reverse MR analyses consistently suggested absent causal relations between psychiatric disorders and AD risk [forward IVW: ORADHD, 1.030, 95% CI, 0.908-1.168, p = 0.674; ORanxiety disorders, 0.904, 95% CI, 0.722-1.131, p = 0.377; ORASD, 0.973, 95% CI, 0.746-1.272, p = 0.846; ORBIP, 1.033, 95% CI, 0.925-1.153, p = 0.564; and ORschizophrenia, 1.039, 95% CI, 0.986-1.095, p = 0.156; reverse IVW: ORADHD, 0.993, 95% CI, 0.954-1.034, p = 0.746; ORanxiety disorders, 1.000, 95% CI, 0.999-1.000, p = 0.898; ORASD, 1.001, 95% CI, 0.962-1.042, p = 0.949; ORBIP, 0.997, 95% CI, 0.966-1.028, p = 0.831; and ORschizophrenia, 1.013, 95% CI, 0.978-1.051, p = 0.466].There is no significant evidence supporting the causal association between the five major psychiatric disorders and AD.
基金:
Beijing Natural Sci- 416
ence Foundation (JQ19024), the National Natural 417
Science Foundation of China (81970996), National 418
Key R&D Program of China (2017YFC1310102 and 419
2019YFC0118200) and Beijing Municipal Science 420
& Technology Commission (Z191100006619046). 421
ZG and YZ were supported by the Edith Cowan 422
University Higher Degree by Research Scholarship 423
(ECU-HDR ST10469322 and ST10468211). This 424
work was also supported by the Centre for Precision 425
Health HDR Student Award ECU (2021-02406- 426
GUO).
第一作者机构:[1]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical.
共同第一作者:
通讯作者:
通讯机构:[1]Innovation Center for Neurological Disorders, Department of Neurology, Xuanwu Hospital, Capital Medical.[4]Neurodegenerative Laboratory of Ministry of Education of the Peoples Republic of China, Beijing, China.[*1]Department of Neurology & Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China
推荐引用方式(GB/T 7714):
Wei Tao,Guo Zheng,Wang Zhibin,et al.Five Major Psychiatric Disorders and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.[J].JOURNAL OF ALZHEIMERS DISEASE.2022,87(2):675-684.doi:10.3233/JAD-220010.
APA:
Wei Tao,Guo Zheng,Wang Zhibin,Li Cancan,Zhu Wei...&Tang Yi.(2022).Five Major Psychiatric Disorders and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study..JOURNAL OF ALZHEIMERS DISEASE,87,(2)
MLA:
Wei Tao,et al."Five Major Psychiatric Disorders and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.".JOURNAL OF ALZHEIMERS DISEASE 87..2(2022):675-684