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Specific structuro-metabolic pattern of thalamic subnuclei in fatal familial insomnia: A PET/MRI imaging study.

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收录情况： ◇ SCIE

作者：
Kexin Xie [a] * ; Yaojing Chen [b] ; Min Chu [a] ; Yue Cui [a] ; Zhongyun Chen [a] ; Jing Zhang [a] ; Li Liu [a,c] ; Donglai Jing [a,d] ; Chunlei Cui [e] ; Zhigang Liang [e] ; Liankun Ren [a] ; Pedro Rosa-Neto [f] ; Imad Ghorayeb [g,h,i] ; Zhanjun Zhang [b,*1] ; Liyong Wu [a,j,*1] ;
机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [b]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China [c]Department of Neurology, Shenyang Fifth People Hospital, Shenyang, Liaoning 110023, China [d]Department of Neurology, Rongcheng People’s Hospital, Baoding, Hebei 071700, China [e]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [f]McGill University Research Centre for Studies in Aging, Montreal, QC H3G 1Y6, Canada [g]Universit´e de Bordeaux, Institut de Neurosciences Cognitives et Int´egratives d’Aquitaine, UMR 5287, F-33076 Bordeaux, France [h]CNRS, Institut de Neurosciences Cognitives et Int´egratives d’Aquitaine, UMR 5287, F-33076 Bordeaux, France [i]D´epartement de Neurophysiologie Clinique, Pˆole Neurosciences Cliniques, CHU de Bordeaux, F-33076 Bordeaux, France [j]National Clinical Research Center for Geriatric Diseases, Beijing 100053, China
出处：
DOI： 10.1016/j.nicl.2022.103026
ISSN：

摘要：
Dysfunction of the thalamus has been proposed as a core mechanism of fatal familial insomnia. However, detailed metabolic and structural alterations in thalamic subnuclei are not well documented. We aimed to address the multimodal structuro-metabolic pattern at the level of the thalamic nuclei in fatal familial insomnia patients, and investigated the clinical presentation of primary thalamic alterations.Five fatal familial insomnia patients and 10 healthy controls were enrolled in this study. All participants underwent neuropsychological assessments, polysomnography, electroencephalogram, and cerebrospinal fluid tests. MRI and fluorodeoxyglucose PET were acquired on a hybrid PET/MRI system. Structural and metabolic changes were compared using voxel-based morphometry analyses and standardized uptake value ratio analyses, focusing on thalamic subnuclei region of interest analyses. Correlation analysis was conducted between gray matter volume and metabolic decrease ratios, and clinical features.The whole-brain analysis showed that gray matter volume decline was confined to the bilateral thalamus and right middle temporal pole in fatal familial insomnia patients, whereas hypometabolism was observed in the bilateral thalamus, basal ganglia, and widespread cortices, mainly in the forebrain. In the regions of interest analysis, gray matter volume and metabolism decreases were prominent in bilateral medial dorsal nuclei, anterior nuclei, and the pulvinar, which is consistent with neuropathological and clinical findings. A positive correlation was found between gray matter volume and metabolic decrease ratios.Our study revealed specific structuro-metabolic pattern of fatal familial insomnia that demonstrated the essential roles of medial dorsal nuclei, anterior nuclei, and pulvinar, which may be a potential biomarker in diagnosis. Also, primary thalamic subnuclei alterations may be correlated with insomnia, neuropsychiatric, and autonomic symptoms sparing primary cortical involvement.Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

基金：
Ministry of Science and Technology of China (2019YFC0118600), the National Natural Science Foundation of China (No. 81971011), and the Beijing Municipal Science and Technology Committee (D171100008217005, 7202060).
语种：
外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 2 区 医学
小类 | 2 区 神经成像
最新[2023]版：
大类 | 2 区 医学
小类 | 2 区 神经成像
JCR分区：
出版当年[2020]版：
Q2 NEUROIMAGING
最新[2023]版：
Q2 NEUROIMAGING

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [b]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China [j]National Clinical Research Center for Geriatric Diseases, Beijing 100053, China [*1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Kexin Xie,Yaojing Chen,Min Chu,et al.Specific structuro-metabolic pattern of thalamic subnuclei in fatal familial insomnia: A PET/MRI imaging study.[J].NEUROIMAGE-CLINICAL.2022,34:doi:10.1016/j.nicl.2022.103026.
APA：
Kexin Xie,Yaojing Chen,Min Chu,Yue Cui,Zhongyun Chen...&Liyong Wu.(2022).Specific structuro-metabolic pattern of thalamic subnuclei in fatal familial insomnia: A PET/MRI imaging study..NEUROIMAGE-CLINICAL,34,
MLA：
Kexin Xie,et al."Specific structuro-metabolic pattern of thalamic subnuclei in fatal familial insomnia: A PET/MRI imaging study.".NEUROIMAGE-CLINICAL 34.(2022)

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