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Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.

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收录情况： ◇ SCIE ◇ 自然指数

作者：
Shuai Ma[1,4,7,14] * ; Si Wang[3,8,14] * ; Yanxia Ye[2,4,7] * ; Jie Ren[4,5,6,12] * ; Ruiqing Chen[9] * ; Wei Li[3,8] ; Jiaming Li[5,6,12] ; Liyun Zhao[3,8] ; Qian Zhao[3,8] ; Guoqiang Sun[2,6] ; Ying Jing[2,6] ; Yuesheng Zuo[5,6] ; Muzhao Xiong[5,6] ; Yuanhan Yang[1,6] ; Qiaoran Wang[5,6] ; Jinghui Lei[3,8] ; Shuhui Sun[1,4,7] ; Xiao Long[11] ; Moshi Song[1,4,7] ; Shuyang Yu[10] ; Piu Chan[3] ; Jianwei Wang[9] ; Qi Zhou[2,4,6,7] ; Juan Carlos Izpisua Belmonte[13] ; Jing Qu[2,4,6,7] ; Weiqi Zhang[4,5,6,7,12,14] ; Guang-Hui Liu[1,3,4,6,7,8] ;
机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu HospitalCapital Medical University, Beijing 100053, China [4]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [5]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China NationalCenter for Bioinformation, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [8]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center,Xuanwu Hospital, Capital Medical University, Beijing 100053, China [9]School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China [10]State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China [11]Division of Plastic Surgery, Peking Union Medical College Hospital, Beijing 100032, China [12]Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China [13]Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA [14]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China
出处：
DOI： 10.1016/j.stem.2022.04.017
ISSN：

摘要：
The young circulatory milieu capable of delaying aging in individual tissues is of interest as rejuvenation strategies, but how it achieves cellular- and systemic-level effects has remained unclear. Here, we constructed a single-cell transcriptomic atlas across aged tissues/organs and their rejuvenation in heterochronic parabiosis (HP), a classical model to study systemic aging. In general, HP rejuvenated adult stem cells and their niches across tissues. In particular, we identified hematopoietic stem and progenitor cells (HSPCs) as one of the most responsive cell types to young blood exposure, from which a continuum of cell state changes across the hematopoietic and immune system emanated, through the restoration of a youthful transcriptional regulatory program and cytokine-mediated cell-cell communications in HSPCs. Moreover, the reintroduction of the identified rejuvenating factors alleviated age-associated lymphopoiesis decline. Overall, we provide comprehensive frameworks to explore aging and rejuvenating trajectories at single-cell resolution and revealed cellular and molecular programs that instruct systemic revitalization by blood-borne factors.Copyright © 2022 Elsevier Inc. All rights reserved.

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外文
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中科院(CAS)分区：
出版当年[2021]版：
大类 | 1 区 医学
小类 | 1 区 细胞与组织工程 1 区 细胞生物学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 细胞与组织工程 1 区 细胞生物学
JCR分区：
出版当年[2020]版：
Q1 CELL BIOLOGY Q1 CELL & TISSUE ENGINEERING
最新[2023]版：
Q1 CELL & TISSUE ENGINEERING Q1 CELL BIOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2020版] 出版当年五年平均 出版前一年[2019版] 出版后一年[2021版]

第一作者：
第一作者机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [4]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [14]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China
共同第一作者：
通讯作者：
通讯机构： [1]State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [2]State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China [3]Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders, Xuanwu HospitalCapital Medical University, Beijing 100053, China [4]Institute for Stem Cell and Regeneration, CAS, Beijing 100101, China [5]CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China NationalCenter for Bioinformation, Beijing 100101, China [6]University of Chinese Academy of Sciences, Beijing 100049, China [7]Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China [8]Aging Translational Medicine Center, International Center for Aging and Cancer, Beijing Municipal Geriatric Medical Research Center,Xuanwu Hospital, Capital Medical University, Beijing 100053, China [12]Sino-Danish College, University of Chinese Academy of Sciences, Beijing, China [14]The Fifth People’s Hospital of Chongqing, Chongqing 400062, China
推荐引用方式(GB/T 7714)：
Shuai Ma,Si Wang,Yanxia Ye,et al.Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.[J].CELL STEM CELL.2022,29(6):990-+.doi:10.1016/j.stem.2022.04.017.
APA：
Shuai Ma,Si Wang,Yanxia Ye,Jie Ren,Ruiqing Chen...&Guang-Hui Liu.(2022).Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues..CELL STEM CELL,29,(6)
MLA：
Shuai Ma,et al."Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.".CELL STEM CELL 29..6(2022):990-+

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