研究单位：[1]Chinese Academy of Medical Sciences, Fuwai Hospital[2]Xuanwu Hospital, Capital Medical University,Beijing, Beijing, China, 100053[3]The general hospital of Chinese People's Liberation Army,Beijing, Beijing, China, 100853[4]The First Affiliated Hospital of Fujian Medical University,Fuzhou, Fujian, China, 350005[5]Nanfang Hospital of southern medical university,Guangzhou, Guangdong, China, 510515[6]Hongxinglong Center Hospital,Shuangyashan, Heilongjiang, China, 155811[7]Henan Provincial People's Hospital,Zhengzhou, Henan, China, 450000[8]TongJi Hospital, TongJi Medical Colleage, HuaZhong University of Science and Technology,Wu Han, Hubei, China, 430000[9]The Third People's Hospital of Xuzhou,Xuzhou, Jiangsu, China, 221005[10]The First Bethun Hospital of Jilin University,Changchun, Jilin, China, 130012[11]Affiliated Hospital of Jining Medical University,Jining, Shandong, China, 272000[12]Qingdao Municipal Hospital,QingDao, Shandong, China, 266300[13]Rizhao Port Hospital,Rizhao, Shandong, China, 276826[14]Ruijin Hospital, Shanghai Jiao Tong University School of Medicine,Shanghai, Shanghai, China, 200025[15]First Hospital of Shanxi Medical University,TaiYuan, Shanxi, China, 030001[16]The fourth military medical university,Xi'an, Shanxi, China[17]West China Hospital，Sichuan Univer,ChengDu, Sichuan, China, 610041[18]Tianjin Chest Hospital,Tianjin, Tianjin, China, 300051
研究目的：
Hypertension is still one of the major preventable risk factor for cardiovascular as well as cerebrovascular diseases globally, including ischaemic heart disease, heart failure, and renal impairment. Despite knowledge on hypertension and the availability of effective antihypertensive medications have progressed dramatically in recent years, the rate of uncontrolled hypertension ( reached 90%) remains high in China[1]. Among those with uncontrolled hypertension，it has been reported that 8.9% in all individuals with hypertension, and 12.8% in the hypertensive drug-treated population[2] are attributed to resistant hypertension. Resistant hypertension has been defined by AHA as high blood pressure (BP) in spite of appropriate lifestyle interventions and treatment of three or more different types of antihypertensive drugs at optimal dose, including at least one diuretics[3,4] or achieving adequate BP control with optimal doses of 4 or more antihypertensive drugs.
At present, not many specifically designed prospective researches concerning resistant hypertension are available. The prevalence of resistant hypertension is not well established and most knowledge about resistant hypertension derives from cross-sectional analyses and clinical trials. The patients with resistant hypertension have been expected to have server target damage, and worse prognosis than those who are non-resistant, but not well established either in the literature[2].
The purpose of this study is to determine the prevalence of resistant hypertension ascertained with systemic investigation and optimal treatment with antihypertensive drugs in community populations and clinic as well as the prognosis among patients with resistant hypertension compared with those who are non-resistant.
