研究单位：[1]Xuanwu Hospital, Beijing[2]University of Pittsburg Medical Center Stroke[3]Baotou Central Hospital,Baotou, China[4]Beijing Luhe Hospital,Beijing, China[5]Beijing Tiantan Hospital,Beijing, China[6]The Military General Hospital of Beijing, PLA,Beijing, China[7]The First People's Hospital of Changzhou,Changzhou, China[8]Chongqing Three Gorges Central Hospital,Chongqing, China[9]Xinqiao Hospital of Chongqing,Chongqing, China[10]Shengli Oilfield Hospital,Dongying, China[11]The Affiliated Hospital Of Guizhou Medical University,Guiyang, China[12]First Hospital of Jilin University,Jilin, China[13]Liaocheng Third People's Hospital,Liaocheng, China[14]Liaocheng Third People's Hospital,Liaocheng, China[15]Luoyang Central Hospital,Luoyang, China[16]Nanjing First People's Hospital,Nanjing, China[17]The First Affiliated Hospital with Nanjing Medical University,Nanjing, China[18]Nanning Second People's Hospital,Nanning, China[19]Nantong University,Nantong, China[20]Nantong University,Nantong, China[21]Changhai Hospital,Shanghai, China[22]Shenzhen Bao'an District People's Hospital ,Shenzhen, China[23]Hebei General Hospital,Shijiazhuang, China[24]Second Affiliated Hospital of Soochow University,Suzhou, China
Endovascular treatment of acute ischemic stroke has shown strong benefit in several prospective randomized trials in the anterior circulation and endovascular therapy for basilar artery occlusion has shown promising results in several single-arm studies. This has led to a broad adoption of these techniques which are now considered standard of care in many institutions despite the lack of adequate evidence to prove their benefit. Indeed, the rates of symptomatic intracerebral hemorrhage in these studies have consistently been around 5% which raises the question as to whether patients could actually be harmed as opposed to helped by these procedures. This is a prospective, multi-center, randomized, controlled, open, blinded-endpoint trial, with the aim to evaluate the hypothesis that mechanical embolectomy with the Solitaire device is superior to medical management alone in achieving better outcomes in subjects presenting with an acute ischemic stroke caused by occlusion of the basilar artery within 6-24 hours from symptom onset.
