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Intracranial Artery Stenosis Magnetic Resonance Imaging: Aetiology and Progression

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研究单位： [1]Tsinghua University [2]Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University,Beijing, China, 100084 [3]Xuanwu Hospital, Beijing [4]Beijing Tiantan Hospital [5]Beijing Hospital [6]309th Hospital of Chinese People's Liberation Army [7]Navy General Hospital, Beijing [8]First Hospitals affiliated to the China PLA General Hospital [9]Beijing Huairou Hospital [10]Beijing Pinggu District Hospital [11]Beijing Shuyi Hospital [12]Tianjin First Central Hospital [13]Tianjin 4th Centre Hospital [14]Tianjin Union Medical Center [15]Hebei Medical University Third Hospital [16]Affiliated Hospital of Chengde Medical University [17]Tangshan Gongren Hospital [18]The First Affiliated Hospital of Hebei North University [19]Cangzhou People's Hospital [20]Harrison International Peace Hospital

关键词： Intracranial artery Atherosclerosis Intracranial artery stenosis High-Resolution Magnetic Resonance

研究目的：

Stroke has become the leading cause of death in China. It has been shown that intracranial artery stenosis (ICAS) plays a key role in Chinese stroke patients. Although most of stenotic diseases in intracranial arteries are atherosclerotic, a substantial number of other vascular diseases, such as dissection, arteritis, moyamoya disease, and reversible cerebral vasoconstriction syndrome (RCVS), can also lead to intracranial artery luminal narrowing. It is challenging to differentiate the etiologies of ICAS relying on measuring luminal narrowing by angiographical approaches. In addition, the progression of intracranial atherosclerotic disease (ICAD) has been demonstrated to be highly associated with the risk of ischemic cerebrovascular events. However, the influence factors for ICAD progression remains unclear. High-resolution magnetic resonance imaging (HR-MRI) has been widely used to assess ICAS diseases. The different etiologies of ICAS are differentiable by MR-MRI according to the features of location, shape, signal pattern, remodeling, and contrast enhancement. Investigators have proved that HR-MRI is a reproducible technique that may be reliably utilized to monitor the changes of ICAD during natural follow-up or medical treatment. The ICASMAP (Intracranial Artery Stenosis MR Imaging: Aetiology and Progression) is a prospective, cross-sectional, observational, and multicenter study. The objectives of ICASMAP are to determine: 1) the spectrum of etiology of ICAS in stroke patients; and 2) the influence factors for progression of ICAD. A total of 300 patients with symptomatic stenotic disease in intracranial arteries (stenosis range: 30%-99%) will be recruited within two weeks after symptom onset from 18 different hospitals across Beijing-Tianjin-Hebei region in China within 1 year. All the patients will undergo HR-MRI for intracranial arteries at baseline, one-year, and two-years. The clinical risk factors will be collected and blood draw will be conducted. The ICASMAP study may help to improve the precise diagnosis and intervention of ICAS and stroke prevention.