研究单位：[1]Biogen[2]Gilbert Neurology Partners, PLLC,Gilbert,Arizona,United States,85297[3]Xenoscience Inc.,Phoenix,Arizona,United States,85004[4]Banner Alzheimer's Institute,Phoenix,Arizona,United States,85006[5]Barrow Neurological Institute,Phoenix,Arizona,United States,85013[6]HonorHealth Neurology,Scottsdale,Arizona,United States,85251[7]Mayo Clinic Arizona,Scottsdale,Arizona,United States,85259[8]Banner Sun Health Research Institute,Sun City,Arizona,United States,85351[9]Banner Alzheimer's Institute,Tucson,Arizona,United States,85012[10]Health Initiatives Research,Fayetteville,Arkansas,United States,72703[11]Sun Valley Behaivoral Med Center,El Centro,California,United States,92243[12]Neuropain Medical Center,Fresno,California,United States,93710[13]Neurology Center of North Orange County,Fullerton,California,United States,92835[14]Irvine Center for Clinical Research, Inc.,Irvine,California,United States,92614[15]Mary S. Easton Center for Alzheimer's Disease Research, UCLA,Los Angeles,California,United States,90095[16]Hoag Memorial Hospital Presbyterian,Newport Beach,California,United States,92663[17]Stanford Hospital and Clinics,Palo Alto,California,United States,94304[18]VA Palo Alto Health Care System,Palo Alto,California,United States,94304[19]Anderson Clinical Research,Redlands,California,United States,92374[20]Sutter Health-San Francisco,San Francisco,California,United States,94115[21]University of California San Francisco (PARENT),San Francisco,California,United States,94143[22]The Neuron Clinic,San Marcos,California,United States,92069[23]Syrentis Clinical Research,Santa Ana,California,United States,92705[24]California Neuroscience Research, LLC,Sherman Oaks,California,United States,91403[25]Viking Clinical Research Center,Temecula,California,United States,92591[26]University of Colorado Anschutz Medical Campus,Aurora,Colorado,United States,80045[27]Mountain Neurological Research Center,Basalt,Colorado,United States,81621[28]Yale University,Fairfield,Connecticut,United States,06824[29]Institute for Neurodegenerative Disorders (IND),New Haven,Connecticut,United States,06510[30]Yale University School Of Medicine,New Haven,Connecticut,United States,06511[31]Research Center for Clinical Studies, Inc.,Norwalk,Connecticut,United States,06851[32]Howard University Health Sciences,Washington,District of Columbia,United States,20060-0002[33]Neurology of Central Florida Research Center, LLC,Altamonte Springs,Florida,United States,32714[34]JEM Research Institute,Atlantis,Florida,United States,33462[35]Neurology Offices of South Florida, PLLC,Boca Raton,Florida,United States,33428[36]Ecommunity Research, LLC,Boca Raton,Florida,United States,33486[37]Nova Clinical Research, LLC,Bradenton,Florida,United States,34209[38]JY Research Institute,Cutler Bay,Florida,United States,45417[39]Brain Matters Research,Delray Beach,Florida,United States,33445[40]Neuropsychiatric Research Center of Southwest Florida,Fort Myers,Florida,United States,33912[41]Infinity Clinical Research, LLC,Hollywood,Florida,United States,33024[42]Charter Research, LLC,Lady Lake,Florida,United States,32159[43]ARS - Lake Oconee,Lakeland,Florida,United States,33803[44]Medical Research Center,Miami,Florida,United States,33165[45]Renstar Medical Research,Ocala,Florida,United States,34470[46]K2 Medical Research, LLC,Ocoee,Florida,United States,34761[47]K2 Medical Research, LLC,Orlando,Florida,United States,32751[48]K2 Medical Research,Orlando,Florida,United States,32751[49]Headlands Research LLC,Orlando,Florida,United States,32819[50]Xuanwu Hospital Capital Medical University,Beijing,China,100053
研究目的：
The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's disease.
