研究单位：[1]Beijing Tiantan Hospital,Capital Medical University[2]Jiangsu FENG HUA Biotech Pharmaceutical Co., Ltd[3]The Place Pharmaceutical(Jiangsu) Co., Ltd[4]Xuancheng People's Hospital,Xuancheng,Anhui,China,242000[5]Beijing Tiantan Hospital, Capital Medical University Beijing,Beijing,Beijing,China,100000[6]Xuanwu Hospital Capital Medical University,Beijing,Beijing,China,100053[7]Three Gorges Hospital Affiliated to Chongqing University,Chongqing,Chongqing,China,404100[8]Quanzhou First Hospital,Quanzhou,Fujian,China,362000[9]Lanzhou University First Hospital,Lanzhou,Gansu,China,730000[10]The Third People's Hospital of Huizhou,Huizhou,Guangdong,China,516000[11]Yuebei People's Hospital,Shaoguan,Guangdong,China,512000[12]The First People's Hospital of Yulin,Yulin,Guangxi,China,541000[13]Handan Central Hospital,Handan,Hebei,China,056000[14]Hengshui people's Hospital (Harrison International Peace Hospital),Hengshui,Hebei,China,053000[15]Tangshan Workers' Hospital,Tangshan,Hebei,China,063000[16]Daqing Oilfield General Hospital,Daqing,Heilongjiang,China,163000[17]Daqing People's Hospital,Daqing,Heilongjiang,China,163000[18]Anyang People's Hospital,Anyang,Henan,China,455100[19]Jiaozuo People's Hospital,Jiaozuo,Henan,China,454000[20]Nanyang South Stone Hospital,Nanyang,Henan,China,473000[21]Pingmei Shenma medical group general hospital,Pingdingshan,Henan,China,467000[22]Xinxiang Central Hospital,Xinxiang,Henan,China,453000[23]Zhoukou Downtown Hospital,Zhoukou,Henan,China,466000[24]The First People's Hospital of Jingzhou,Jingzhou,,Hubei,China,434000[25]Baogang Hospital of Inner Monglia,Baotou,Inner Monglia,China,014010[26]Baotou Central Hospital,Baotou,Inner Mongolia,China,014010[27]Keshenketengqi Mongolian Medicine Hospital,Chifeng,Inner Mongolia,China,025300[28]The Second Affiliated Hospital of Suzhou Medical University,Suzhou,Jiangsu,China,215000[29]Taizhou People's Hospital,Taizhou,Jiangsu,China,225300[30]Xuzhou Central Hospital,Xuzhou,Jiangsu,China,221000[31]Xuzhou Mining Group General Hospital,Xuzhou,Jiangsu,China,221000[32]The Affiliated Hospital of Xuhzou Meidcal University,Xuzhou,Jiangsu,China,221006[33]The First Hospital of Jilin University,Changchun,Jilin,China,130021[34]Jilin Guowen Hospital,Siping,Jilin,China,136000[35]Siping Central People's Hospital,Siping,Jilin,China,136000[36]Tonghua Central Hospital,Tonghua,Jilin,China,134100[37]Meihekou Central Hospital,Tonghua,Jilin,China,135000[38]Beipiao Central Hospital,Beipiao,Liaoning,China,122000[39]Dalian Central Hospital,Dalian,Liaoning,China,116000[40]Fushun Mining Bureau General Hospital,Fushun,Liaoning,China,113000[41]Liaoning Health Industry Group Fuxin Mine General Hospital,Fuxin,Liaoning,China,123100[42]The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning,China,121000[43]Affiliated Central Hospital of Shenyang Medical College,ShenYang,Liaoning,China,111000[44]Air Force Hospital of Northern War Zone,PLA,Shenyang,Liaoning,China,111000[45]General Hospital of Northern War Zone,PLA,Shenyang,Liaoning,China,111000[46]The First Affiliated Hospital of China Medical University,ShenYang,Liaoning,China,111000[47]The First People's Hospital of Shenyang,Shenyang,Liaoning,China,111000[48]General Hospital of Ningxia Medical University Cardio-cerebral Vascular Disease Hospital,Yinchuan,Ningxia,China,750000[49]The First People's Hospital of Yinchuan,Yinchuan,Ningxia,China,750000[50]Dezhou Hospital of Shandong University Qilu Hospital (Dezhou People's Hospital),Dezhou,Shandong,China,253000[51]Jinan People's Hospital,Jinan,Shandong,China,250000[52]Qilu Hospital of Shandong University,Jinan,Shandong,China,250012[53]Liaocheng People's Hospital,Liaocheng,Shandong,China,252006[54]Linyi Hospital of Traditional Chinese Medicine,Linyi,Shandong,China,273300[55]Linyi People's Hospital,Linyi,Shandong,China,273300[56]The First People's Hospital of Tancheng County,Linyi,Shandon
The trial is prospective, randomized, open-label, blinded endpoint (PROBE) design. Patients with acute ischemic stroke, who are eligible for standard intravenous thrombolysis within 4.5 hours of stroke onset will be randomized 1:1 to 0.25mg/kg or 0.9 mg/kg alteplase before all participants undergo endovascular thrombectomy.
