研究单位:[1]Xuanwu Hospital, Beijing[2]Ningcheng Center Hospital[3]Changning Mental Health Center[4]Tianjin Anding Hospital[5]Kangning Hospital, Ningbo University
This trial aims to investigate the effect of twice-daily 15 mA transcranial alternating current stimulation (tACS) through three conductive electrodes attached to the scalp in subjects with treatment-resistant depression (TRD). Two hundred adult subjects with TRD will be included in this randomized, double-blind, parallelized, multi-centre study. The primary outcome is the change of the Montgomery-Asberg Depression Rating Scale (MADRS) after four weeks of tACS.