研究单位：[1]Xuanwu Hospital, Capital Medical University,Beijing,China,100053[2]Beijing Luhe Hospital affiliated to Capital Medical University,Beijing,Beijing,China,100000[3]Beijing Fangshan District First Hospital,Beijing,Beijing,China,100010[4]Shenzhen qianhai shekou free trade zone hospital,Shenzhen,Guangdong,China,518000[5]South China Hospital Affiliated to Shenzhen University,Shenzhen,Guangdong,China,518000[6]Nanning Second People's Hospital,Nanning,Guangxi,China,530000[7]Jiamusi university hongda hospital,Jiamusi,Heilongjiang,China,154000[8]Jiaozuo Coal Industry Group Co., Ltd. Central Hospital,Jiaozuo,Henan,China,454000[9]Luoyang Yanshi People's Hospital,Luoyang,Henan,China,471000[10]Henan Province People's Hospital,Zhengzhou,Henan,China,450000[11]Xihua county people's hospital,Zhoukou,Henan,China,466600[12]Huanggang Centralhospital,Huanggang,Hubei,China,438000[13]Huangshi central hospital,Huangshi,Hubei,China,435000[14]Jingmen No.1 People's Hospital,Jingmen,Hubei,China,448000[15]Jingmen people's hospital,Jingmen,Hubei,China,448000[16]First People's Hospital of Tianmen,Tianmen,Hubei,China,430000[17]Wuhan University Zhongnan Hospital,Wuhan,Hubei,China,430000[18]The First People's Hospital of Xiangyang,Xiangyang,Hubei,China,441000[19]Yichang Central People's Hospital,Yichang,Hubei,China,443000[20]the First People'S Hospital of Changde,Changde,Hunan,China,415000[21]The Third Xiangya Hospital of Central South University,Changsha,Hunan,China,410000[22]Xiangya Hospital, Central South University,Changsha,Hunan,China,410000[23]Inner Mongolia Autonomous Region People's Hospital,Hohhot,Inner Mongolia Autonomous Region,China,010000[24]Anshan zhangda hospital,Anshan,Liaoning,China,Anshan[25]Dalian Central Hospital,Dalian,Liaoning,China,116000[26]The Central Hospital of Shengli Oilfield,Dongying,Shandong,China,257000[27]Liaocheng Third People's Hospital,Liaocheng,Shandong,China,252000[28]The People's Hospital of Liaocheng Brain Hospital,Liaocheng,Shandong,China,252000[29]Feixian county people's hospital,Linyi,Shandong,China,273400[30]Mianyang third people's hospital,Mianyang,Sichuan,China,621000[31]Ya 'an People's Hospital,Ya'an,Sichuan,China,625000[32]Tianjin huanhu hospital,Tianjin,Tianjin,China,300000[33]The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China,325000
For patients with acute ischemic stroke caused by large vessel occlusion, endovascular thrombectomy has been demonstrated to be the most effective therapy, as approximately 90% of the occluded vessels can be recanalized. However, less than 50% of patients could achieve functional independence, and over 15% died 90 days after stroke. Although the mismatch of successful recanalization with poor prognosis can be attributed to many factors, the infarct core formed during thrombectomy and reperfusion injury after thrombectomy may be among the most important and effective neuroprotective strategies urgently needed. Remote ischemic conditioning (RIC) is a noninvasive strategy in which one or more cycles of brief and transient limb ischemia confer protection against prolonged and severe ischemia in distant organs. In the transient focal cerebral ischemia-reperfusion model, the application of remote ischemic conditioning before reperfusion or both before and after reperfusion reduces reperfusion injuries and the final infarct size. Because patients with acute ischemic stroke who are treated with endovascular thrombectomy can achieve a high rate of recanalization after focal ischemia, this patient population is akin to the model of transient focal cerebral ischemia-reperfusion. Furthermore, a pilot study has determined the safety and feasibility of remote ischemic conditioning in patients undergoing endovascular thrombectomy. However, whether remote ischemic conditioning could provide clinical benefits to patients with acute ischemic stroke who are treated with endovascular thrombectomy urgently needs investigations. This study aims to investigate the safety and efficacy of remote ischemic conditioning in improving functional outcomes of patients with acute ischemic stroke treated with endovascular thrombectomy and explore the effect of treatment duration on the treatment outcome of remote ischemic conditioning.
