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Role and Mechanism of Probiotics in Improving Motor Symptoms in Mild to Moderate Parkinson's Disease

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研究单位： [1]Beijing Friendship Hospital [2]Peking University First Hospital Beijing,Beijing,China,100034 [3]Beijing Friendship Hospital Beijing,Beijing,China,100050 [4]Beijing Tiantan Hospital,Capital Medical University Beijing,Beijing,China,100050 [5]Xuanwu Hospital Capital Medical University Beijing,Beijing,China,100053 [6]Peking University Third Hospital Beijing,Beijing,China,100191 [7]Beijing Hospital Beijing,Beijing,China,100730 [8]Peking Union Medical College Hospital Beijing,Beijing,China,100730 [9]Jinan Central Hospital Jinan,Shandong,China,250013 [10]Shanghai Changzheng Hospital Shanghai,Shanghai,China,200003

研究目的：

This study is a multicenter randomized double-blind placebo-controlled study. The research content is 1. The improvement effect of Bifidobacterium triple viable capsules（BIFICO） on motor symptoms and constipation and sleep in mild to moderate Parkinson's disease and the safety of the study; 2. the mechanism of the improvement effect of intestinal microecological changes on motor and constipation symptoms in mild to moderate Parkinson's disease.