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Generative adversarial network constrained multiple loss autoencoder: A deep learning-based individual atrophy detection for Alzheimer's disease and mild cognitive impairment

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机构: [1]School of Information and Communication Engineering, Shanghai University, Shanghai, China. [2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [3]Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China. [4]College of Computing and Informatics, Drexel University, Philadelphia, Pennsylvania, USA. [5]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [6]National Clinical Research Center for Geriatric Disorders, Beijing, China. [7]Institute of Biomedical Engineering, School of Life Science, Shanghai University, Shanghai, China.
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关键词: Alzheimer's disease GAN magnetic resonance imaging precision medicine

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Exploring individual brain atrophy patterns is of great value in precision medicine for Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, the current individual brain atrophy detection models are deficient. Here, we proposed a framework called generative adversarial network constrained multiple loss autoencoder (GANCMLAE) for precisely depicting individual atrophy patterns. The GANCMLAE model was trained using normal controls (NCs) from the Alzheimer's Disease Neuroimaging Initiative cohort, and the Xuanwu cohort was employed to validate the robustness of the model. The potential of the model for identifying different atrophy patterns of MCI subtypes was also assessed. Furthermore, the clinical application potential of the GANCMLAE model was investigated. The results showed that the model can achieve good image reconstruction performance on the structural similarity index measure (0.929 ± 0.003), peak signal-to-noise ratio (31.04 ± 0.09), and mean squared error (0.0014 ± 0.0001) with less latent loss in the Xuanwu cohort. The individual atrophy patterns extracted from this model are more precise in reflecting the clinical symptoms of MCI subtypes. The individual atrophy patterns exhibit a better discriminative power in identifying patients with AD and MCI from NCs than those of the t-test model, with areas under the receiver operating characteristic curve of 0.867 (95%: 0.837-0.897) and 0.752 (95%: 0.71-0.790), respectively. Similar findings are also reported in the AD and MCI subgroups. In conclusion, the GANCMLAE model can serve as an effective tool for individualised atrophy detection.© 2022 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.

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出版当年[2022]版:
大类 | 2 区 医学
小类 | 2 区 神经成像 2 区 神经科学 2 区 核医学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 神经成像 2 区 核医学 3 区 神经科学
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出版当年[2021]版:
Q1 NEUROIMAGING Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 NEUROSCIENCES
最新[2024]版:
Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Q2 NEUROIMAGING Q2 NEUROSCIENCES

影响因子: 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]School of Information and Communication Engineering, Shanghai University, Shanghai, China.
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通讯机构: [2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China. [3]Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China. [5]Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, China. [6]National Clinical Research Center for Geriatric Disorders, Beijing, China. [7]Institute of Biomedical Engineering, School of Life Science, Shanghai University, Shanghai, China. [*1]Institute of Biomedical Engineering, School of Information and Communication Engineering, Shanghai University, Shanghai 200444, China [*2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China.
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