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Vascular endothelial cells: a fundamental approach for brain waste clearance

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ 自然指数

作者：
Wei Huimin[1,2] * ; Jiang Huimin[2] * ; Zhou Yifan[2] ; Xiao Xuechun[1,2] ; Zhou Chen[2,*2] ; Ji Xunming[1,2,3,*1] ;
机构： [1]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China. [2]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Beijing Advanced Innovation Center for Big Data-based Precision Medicine, Capital Medical University, Beijing, 100069, China. [3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China.
出处：
DOI： 10.1093/brain/awac495
ISSN：

摘要：
Accumulation of neurotoxic protein aggregates is the pathological hallmark of neurodegenerative disease. Proper clearance of these waste metabolites is an essential process for maintaining brain microenvironment homeostasis and may delay or even halt the onset and progression of neurodegeneration. Vascular endothelial cells regulate the molecular exchange between the circulation and brain parenchyma, thereby protecting the brain against the entry of xenobiotics and decreasing the accumulation of neurotoxic proteins. In this review, we provide an overview of cerebrovascular endothelial cell characteristics and their impact on waste metabolite clearance. Lastly, we speculate that molecular changes in cerebrovascular endothelial cells are the drivers of neurodegenerative diseases.© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

基金：
This study was supported by the Cheung Kong (Changjiang) Scholars Program (T2014251), the Pharmaceutical Collaboration Project of Beijing Science and Technology Commission (Z18110000191 8026), grants from National Natural Science Foundation of China (82271311).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 神经科学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学 1 区 神经科学
JCR分区：
出版当年[2021]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES
最新[2024]版：
Q1 CLINICAL NEUROLOGY Q1 NEUROSCIENCES

影响因子： 最新[2024版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China. [2]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Beijing Advanced Innovation Center for Big Data-based Precision Medicine, Capital Medical University, Beijing, 100069, China.
共同第一作者：
通讯作者：
通讯机构： [1]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China. [2]Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Beijing Advanced Innovation Center for Big Data-based Precision Medicine, Capital Medical University, Beijing, 100069, China. [3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, 100053, China. [*1]No. 37 Xueyuan Road, Haidian District, Beijing, 100191, China [*2]No.10 Xitoutiao, You An Men, Beijing 100069, China
推荐引用方式(GB/T 7714)：
Wei Huimin,Jiang Huimin,Zhou Yifan,et al.Vascular endothelial cells: a fundamental approach for brain waste clearance[J].BRAIN.2023,146(4):1299-1315.doi:10.1093/brain/awac495.
APA：
Wei Huimin,Jiang Huimin,Zhou Yifan,Xiao Xuechun,Zhou Chen&Ji Xunming.(2023).Vascular endothelial cells: a fundamental approach for brain waste clearance.BRAIN,146,(4)
MLA：
Wei Huimin,et al."Vascular endothelial cells: a fundamental approach for brain waste clearance".BRAIN 146..4(2023):1299-1315

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