The aim of the article is to introduce a novel laser-based frameless stereotactic device that can locate intracranial lesions quickly and with CT/MRI films. Preliminary experiences of application in 416 cases will also be summarized.From August in 2020 to October in 2022, a total of 416 cases of new minimalist laser stereotactic surgery have been performed on 415 patients. Of the 415 patients, 377 had intracranial hematomas, while the remaining cases were brain tumors or brain abscesses. Postoperative CT was used to evaluate the accuracy of 405 patients of catheterization according to the MISTIE study.The duration time of locating was recorded. Rebleeding refers to HE definition: Compared with preoperative CT, the relative volume of postoperative hematoma increases by >33% or Absolute volume increase >12.5ml.According to postoperative CT, the accuracy of 405 stereotactic catheterization cases were good in 346 cases (85.4%) and suboptimal in 59 cases (14.6%), with no poor results. Postoperative rebleeding occurred in 4 spontaneous cerebral hemorrhage cases and one brain biopsy case. The average localization time of supratentorial lesions was 13.2 minutes in the supine position, 21.5 minutes in the lateral position, and 27.6 minutes in the prone position.The new laser-based frameless stereotactic device is simple in principle and convenient in positioning operation of brain hematoma and abscess puncture, brain biopsy and tumor surgery, and capable the needs of precision in most craniocerebral surgery.Copyright © 2023. Published by Elsevier Inc.