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Specific Alterations in Brain White Matter Networks and Their Impact on Clinical Function in Pediatric Patients With Thoracolumbar Spinal Cord Injury

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收录情况： ◇ SCIE

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机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China. [3]Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. [4]Department of Medical Imaging, Affiliated Hospital of Hebei Engineering University, Handan, China. [5]Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. [6]Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [7]Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.

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The alternation of brain white matter (WM) network has been studied in adult spinal cord injury (SCI) patients. However, the WM network alterations in pediatric SCI patients remain unclear.To evaluate WM network changes and their functional impact in children with thoracolumbar SCI (TSCI).Prospective.Thirty-five pediatric patients with TSCI (8.94 ± 1.86 years, 8/27 males/females) and 34 age- and gender-matched healthy controls (HCs) participated in this study.3.0 T/DTI imaging using spin-echo echo-planar and T1-weighted imaging using 3D T1-weighted magnetization-prepared rapid gradient-echo sequence.Pediatric SCI patients were evaluated for motor and sensory scores, injury level, time since injury, and age at injury. The WM network was constructed using a continuous tracing method, resulting in a 90 × 90 matrix. The global and regional metrics were obtained to investigate the alterations of the WM structural network. topology.Two-sample independent t-tests, chi-squared test, Mann-Whitney U-test, and Spearman correlation. Statistical significance was set at P < 0.05.Compared with HCs, pediatric TSCI patients displayed decreased shortest path length (Lp = 1.080 ± 0.130) and normalized Lp (λ = 5.020 ± 0.363), and increased global efficiency (Eg = 0.200 ± 0.015). Notably, these patients also demonstrated heightened regional properties in the orbitofrontal cortex, limbic system, default mode network, and several audio-visual-related regions. Moreover, the λ and Lp values negatively correlated with sensory scores. Conversely, nodal efficiency values in the right calcarine fissure and surrounding cortex positively correlated with sensory scores. The age at injury positively correlated with node degree in the left parahippocampal gyrus and nodal efficiency in the right posterior cingulate gyrus.Reorganization of the WM networks in pediatric SCI patients is indicated by increased global and nodal efficiency, which may provide promising neuroimaging biomarkers for functional assessment of pediatric SCI.2 TECHNICAL EFFICACY: Stage 5.© 2024 International Society for Magnetic Resonance in Medicine.

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出版当年[2023]版：

大类 | 2 区医学

小类 | 2 区核医学

最新[2025]版：

大类 | 2 区医学

小类 | 3 区核医学

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出版当年[2022]版：

Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

最新[2024]版：

Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 3.5 最新[2024版] 4.3 最新五年平均 4.4 出版当年[2022版] 4.5 出版当年五年平均 5.119 出版前一年[2021版] 3.3 出版后一年[2023版]

第一作者：

第一作者机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China.

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通讯作者：

通讯机构： [1]Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China.

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