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Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Pin[1] * ; Sun Wenxian[1] ; Gong Jin[2] ; Han Xiaodong[1] ; Xu Chang[1] ; Chen Yufei[1] ; Yang Yuting[3] ; Luan Heya[1] ; Li Shaoqi[2] ; Li Ruina[3] ; Wen Boye[1] ; Lv Sirong[1] ; Chen Runqi[3] ; Guo Jinxuan[2] ; Wei Cuibai[1] ;
机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China [2]College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China [3]School of Biological Science and Medical Engineering, Beihang University, Beijing, China
出处：
DOI： 10.1016/j.scr.2024.103398
ISSN：

摘要：
Genetic polymorphism of apolipoprotein E (APOE) confers differential susceptibility to Alzheimer's disease (AD), and APOE ɛ4 variants is the most powerful risk factor for this disease. Here, we report the generation of a human induced pluripotent stem cell (iPSC) line carrying the APOE ɛ4/ɛ4 genotype from peripheral blood mononuclear cells (PBMCs) isolated from a male with a family history of AD utilizing non-integrative Sendai virus vector. The iPSC maintains their original genotype, highly express endogenous pluripotency markers, displays a normal karyotype, and retains the ability to differentiate into cells representative of the three germ layers.Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.

基金：
This study was supported by STI2030-Major Projects (No.2021ZD0201802) to Dr. Cuibai Wei.
语种：
外文
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2023]版：
大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 细胞与组织工程 4 区 细胞生物学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 生物工程与应用微生物 4 区 细胞与组织工程 4 区 细胞生物学
JCR分区：
出版当年[2022]版：
Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY
最新[2024]版：
Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Q4 CELL & TISSUE ENGINEERING Q4 CELL BIOLOGY

影响因子： 最新[2024版] 最新五年平均 出版当年[2022版] 出版当年五年平均 出版前一年[2021版] 出版后一年[2023版]

第一作者：
第一作者机构： [1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China
通讯作者：
推荐引用方式(GB/T 7714)：
Wang Pin,Sun Wenxian,Gong Jin,et al.Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation[J].Stem Cell Research.2024,77:103398.doi:10.1016/j.scr.2024.103398.
APA：
Wang Pin,Sun Wenxian,Gong Jin,Han Xiaodong,Xu Chang...&Wei Cuibai.(2024).Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation.Stem Cell Research,77,
MLA：
Wang Pin,et al."Generation of human induced pluripotent stem cell line (XWHNi004-A) from a male with APOE gene mutation".Stem Cell Research 77.(2024):103398

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