Background: Clinical features of fungal infection in infected pancreatic necrosis (IPN)patients have not been fully elucidated. Methods: The clinical data of patients with IPN admitted to Xuanwu Hospital Capital Medical University from January 1, 2017 to December 31, 2021 were analyzed. According to the results of pancreatic necrotic tissue and drainage fluid culture, patients were divided into the group with fungal infection and without fungal infection. The baseline data, clinical feature and outcomes of the two groups were compared, and the risk factors of death in patients with fungal infection were also analyzed. Results: In 214 IPN patients, 49 complicated with fungal infection, and Candida albicans (44.8%) was the most common fungus detected, followed by Candida parapsilosis (28.6%) and Candida tropicalis (8.2%). IPN patients with fungal infection had wider necrotic involvement, lower hematopoietic volume, and higher blood glucose at admission. Multidrug-resistant bacteria (MDRB) infection was common in these patients(78% vs. 55%, p = 0.004), and the total number of days in hospital and in ICU were also longer. Fungal infection did not increase the possibility of surgical debridement, but led to more organ failure and death. Logistic regression analysis showed that MDRB infection[OR = 1.37(1.02-1.83)], fungemia[OR = 1.53(1.06-2.23)], hyperglycemia[OR = 1.65(1.28-2.10)], new organ failure[OR = 1.65(1.19-2.29)] and hemorrhage[OR = 1.64(1.28-2.10)] after surgery were risk factors for death in patients with fungal infection.