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Deep-Learning-Based Texture Enhancement of Low-Resolution Brain T1-Weighted Magnetic Resonance Imaging for Alzheimer's Disease Diagnosis

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机构: [1]Shanghai Univ, Inst Biomed Engn, Sch Life Sci, Shanghai 200444, Peoples R China [2]Wuhan Univ, Dept Neuropsychol, Zhongnan Hosp, Wuhan 430071, Hubei, Peoples R China [3]Capital Med Univ, Xuanwu Hosp, Dept Radiol & Nucl Med, Beijing 100053, Peoples R China [4]Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Dept Neurol, Shanghai 200437, Peoples R China [5]Capital Med Univ, Beijing Friendship Hosp, Beijing 100050, Peoples R China
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关键词: Alzheimer's disease magnetic resonance imaging generative adversarial network imaging enhancement texture analysis

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Texture analysis in T1-Weighted Magnetic Resonance Imaging (T1WI) with high spatial resolution can identify unique texture patterns in brain tissue associated with Alzheimer's Disease (AD). However, texture feature extraction from Low-Resolution (LR) T1WI presents significant technical challenges due to inherent information loss. In this work, we proposed TE-CGAN, a Texture-Enhanced Cycle Generative Adversarial Network for high-quality texture feature extraction from LR T1WI. Specifically, a hybrid loss was constructed to transform the complex voxel-wise multi-feature encoding learning task into multiple low-dimensional learning tasks, including structural preservation, perceptual consistency, and texture enhancement, to increase the global and local quality of synthesized T1WI. A total of 1358 scans of brain T1WI from 995 subjects derived from data pools of neural imaging research in Tongji Hospital (781 subjects, 1144 scans) and Xuanwu Hospital (214 subjects, 214 scans) were included. In parallel comparison with six generated methods, we comprehensively evaluated (a) the quality of synthesized imaging, (b) the precision of texture features, and (c) AD-related application scenarios. Compared with other methods included in our study, TE-CGAN-synthesized T1WI demonstrated superior performance across both conventional image quality metrics (Peak Signal-to-Noise Ratio = 30.23 dB; Structural Similarity Index = 0.88) and texture feature fidelity (Pearson Correlation = 0.93). Even without retraining or fine-tuning, TE-CGAN demonstrated superior performance in texture-based clinical diagnosis within the external test set compared to other approaches. Our study validated the use of TE-CGAN for enhancing LR T1WI texture features, demonstrating potential application value in clinical practice and neuroscience research.

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出版当年[2025]版:
大类 | 2 区 计算机科学
小类 | 2 区 工程:电子与电气 2 区 电信学
最新[2025]版:
大类 | 2 区 计算机科学
小类 | 2 区 工程:电子与电气 2 区 电信学
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出版当年[2023]版:
Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Q2 TELECOMMUNICATIONS
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Q1 ENGINEERING, ELECTRICAL & ELECTRONIC Q1 TELECOMMUNICATIONS

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第一作者机构: [1]Shanghai Univ, Inst Biomed Engn, Sch Life Sci, Shanghai 200444, Peoples R China
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