BackgroundIncreasing evidence has demonstrated a causal relationship between cerebrovascular disease (CVD) and cardiovascular events. This study investigated the effects of previous CVD on the in-hospital characteristics and prognosis of patients with first-ever acute myocardial infarction (AMI).MethodsThis study recruited 2993 consecutive patients diagnosed with AMI between January 2017 and December 2022. Baseline characteristics, general evaluations, and cardiac tests were compared between patients with AMI with and without a history of CVD (CVD group and nCVD group, respectively). The primary outcome was major adverse cardiovascular events (MACEs). The secondary outcome was extended length of stay (LOSE). Baseline characteristics were balanced using 1:1 propensity score matching (PSM).ResultsThis study enrolled 536 patients with first-ever AMI after PAM. Compared with patients in the nCVD group, those in the CVD group had higher high-sensitivity C-reactive protein (p = 0.04) and N-terminal pro-B-type natriuretic peptide (p = 0.002) levels, as well as a lower left ventricular ejection fraction (p = 0.004). The CVD group also showed a lower percentage of moderate risk (p = 0.03) and a higher percentage of high risk (p = 0.03) GRACE scores on admission, in addition to a higher overall GRACE score before discharge (p = 0.04) compared with patients in the nCVD group. However, the risk of MACE or LOSE did not differ significantly between patients in the CVD and nCVD groups.ConclusionPatients with AMI and a history of CVD may experience severe damage to cardiac structure and function. However, a history of CVD was not associated with in-hospital outcomes in patients with AMI.