机构：[1]Department of Pharmacology, Nanjing Medical University, Nanjing, China[2]Department of Pharmacy, Second Affiliated Hospital of Soochow University, Suzhou, China
In neurons, increased protein-protein interactions between neuronal nitric oxide synthase (nNOS) and its carboxy-terminal PDZ ligand (CAPON) contribute to excitotoxicity and abnormal dendritic spine development, both of which are involved in the development of Alzheimer's disease. In models of Alzheimer's disease, increased nNOS-CAPON interaction was detected after treatment with amyloid-beta in vitro, and a similar change was found in the hippocampus of APP/PS1 mice (a transgenic mouse model of Alzheimer's disease), compared with age-matched background mice in vivo. After blocking the nNOS-CAPON interaction, memory was rescued in 4-month-old APP/PS1 mice, and dendritic impairments were ameliorated both in vivo and in vitro. Furthermore, we demonstrated that S-nitrosylation of Dexras1 and inhibition of the ERK-CREB-BDNF pathway might be downstream of the nNOS-CAPON interaction.
基金：
This work was supported by the National
Natural Science Foundation of China (Grant
/ Award Number: 31530091) and the
Natural Science Foundation of Jiangsu
Province (Grant / Award Number:
BK20140905).
第一作者机构：[1]Department of Pharmacology, Nanjing Medical University, Nanjing, China
通讯作者：
通讯机构：[*1]Department of Pharmacology, Nanjing Medical University, Jiangning District, Nanjing, China.
推荐引用方式(GB/T 7714)：
Yu Zhang,Zhu Zhu,Hai-Ying Liang,et al.nNOS-CAPON interaction mediates amyloid-beta-induced neurotoxicity, especially in the early stages[J].AGING CELL.2018,17(3):e12754.doi:10.1111/acel.12754.
APA：
Yu Zhang,Zhu Zhu,Hai-Ying Liang,Lei Zhang,Qi-Gang Zhou...&Dong-Ya Zhu.(2018).nNOS-CAPON interaction mediates amyloid-beta-induced neurotoxicity, especially in the early stages.AGING CELL,17,(3)
MLA：
Yu Zhang,et al."nNOS-CAPON interaction mediates amyloid-beta-induced neurotoxicity, especially in the early stages".AGING CELL 17..3(2018):e12754
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