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Identification of carotid lipid-rich necrotic core and calcification by 3D magnetization-prepared rapid acquisition gradient-echo imaging

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收录情况： ◇ SCIE

作者：
Qiao, Huiyu[1] * ; Li, Feiyu[2] ; Xu, Dongxiang[3] ; Liu, Gaifen[4] ; Yuan, Chun[1,3] ; Zhao, Xihai[1,*1] ;
机构： [1]Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China [2]Department of Radiology, Peking University First Hospital, Beijing, China [3]Department of Radiology, University of Washington, Seattle, WA, USA [4]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.mri.2018.07.004
ISSN：

关键词： Carotid atherosclerosis Lipid-rich necrotic core Calcification Magnetization-prepared rapid acquisition gradient-echo

摘要：
Background and purpose: This study sought to investigate the feasibility of three-dimensional MPRAGE in identifying the lipid-rich necrotic core (LRNC) and calcification (CA) of carotid atherosclerotic plaques. Materials and methods: Twelve patients (mean age 68A +/- 11.8 years; 7 males) with carotid atherosclerotic plaques on ultrasound were included and underwent multicontrast magnetic resonance (MR) vessel wall imaging. The contrast enhanced T1W (CE-T1W) images were considered as reference for identifying LRNC. The signal intensity of LRNC, CA, sterno-cleidomastoid muscle and fibrous tissue (FT) was measured on CE-T1W, T1W, T2W, and MPRAGE images, respectively. The relative signal intensity (rSI) of LRNC and CA against muscle or FT was compared among four sequences. Area under the curve (AUC) of rSIs of LRNC, CA and FT against muscle on MPRAGE, T1W and T2W images in discriminating the LRNC or CA from FT and the other plaque component was calculated. Results: Of 352 slices, 88 (25.0%) had LRNC, 31 (8.8%) had CA, 14 (4.0%) had both LRNC and CA, and 247 (70.2%) had no components. Among four imaging sequences, MPRAGE images showed the lowest rSI of LRNC (0.34 +/- 0.18) and CA (0.20 +/- 0.16) against muscle, followed by T1W (0.48 +/- 0.18 and 0.33 +/- 0.21), CE-T1W (0.58 +/- 0.23 and 0.40 +/- 0.21) and T2W (0.71 +/- 0.47 and 0.43 +/- 0.40) images. In addition, the MPRAGE images showed the lowest rSI of LRNC (0.57 +/- 0.26) and CA (0.33 +/- 0.23) against FT. MPRAGE showed greater AUC than T2W and T1W in discriminating the LRNC (0.827 vs. 0.703 vs. 0.635) and CA (0.917 vs. 0.838 vs. 0.825). Conclusion: MPRAGE sequence might be a potential non-contrast enhanced imaging tool for identification of carotid LRNC and CA.

基金：
grants of Beijing Municipal Science and Technology Project [D171100003017003]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81771825, 81271536]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 4 区 医学
小类 | 3 区 核医学
最新[2025]版：
大类 | 4 区 医学
小类 | 4 区 核医学
JCR分区：
出版当年[2016]版：
Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
最新[2024]版：
Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

影响因子： 最新[2024版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China
通讯作者：
通讯机构： [1]Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China [*1]Center for Biomedical Imaging Research, Tsinghua University School of Medicine, Haidian District, 100084 Beijing, China
推荐引用方式(GB/T 7714)：
Qiao Huiyu,Li Feiyu,Xu Dongxiang,et al.Identification of carotid lipid-rich necrotic core and calcification by 3D magnetization-prepared rapid acquisition gradient-echo imaging[J].MAGNETIC RESONANCE IMAGING.2018,53:71-76.doi:10.1016/j.mri.2018.07.004.
APA：
Qiao, Huiyu,Li, Feiyu,Xu, Dongxiang,Liu, Gaifen,Yuan, Chun&Zhao, Xihai.(2018).Identification of carotid lipid-rich necrotic core and calcification by 3D magnetization-prepared rapid acquisition gradient-echo imaging.MAGNETIC RESONANCE IMAGING,53,
MLA：
Qiao, Huiyu,et al."Identification of carotid lipid-rich necrotic core and calcification by 3D magnetization-prepared rapid acquisition gradient-echo imaging".MAGNETIC RESONANCE IMAGING 53.(2018):71-76

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