机构：[1]Sungkyunkwan Univ Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea;[2]APFID, Seoul, South Korea;[3]Natl Taiwan Univ Hosp, Dept Lab Med & Internal Med, Taipei, Taiwan;[4]Sungkyunkwan Univ Sch Med, Dept Mol & Cell Biol, Suwon, South Korea;[5]Sungkyunkwan Univ Sch Med, Kangbuk Samsung Hosp, Seoul, South Korea;[6]Kyungpook Natl Univ Hosp, Taegu, South Korea;[7]Chungnam Natl Univ Hosp, Taejon, South Korea;[8]Chonnam Natl Univ Med Sch, Kwangju, South Korea;[9]Kyung Hee Univ, EW Neo Med Ctr, Seoul, South Korea;[10]Princess Margaret Hosp, Hong Kong, Hong Kong, Peoples R China;[11]Christian Med Coll & Hosp, Vellore 632004, Tamil Nadu, India;[12]Beijing Childrens Hosp, Beijing, Peoples R China;首都医科大学附属北京儿童医院[13]Rui Jin Hosp, Shanghai, Peoples R China;[14]Beijing Union Med Coll Hosp, Beijing, Peoples R China;[15]Changhai Childrens Hosp, Shanghai, Peoples R China;[16]Res Inst Trop Med, Manila, Philippines;[17]Univ Colombo, Colombo, Sri Lanka;[18]Chang Gung Childrens Hosp, Taipei, Taiwan;[19]Chang Gung Med Coll, Chang Gung Mem Hosp Kaohsiung Med Ctr, Taipei, Taiwan;[20]Chulalongkorn Univ, Bangkok, Thailand;[21]Mahidol Univ, Siriraj Hosp, Bangkok 10700, Thailand;[22]Univ Med & Pharm, Ho Chi Minh City, Vietnam
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is highly prevalent in hospitals in many Asian countries. Recent emergence of community-associated (CA) MRSA worldwide has added another serious concern to the epidemiology of S. aureus infections. To understand the changing epidemiology of S. aureus infections in Asian countries, we performed a prospective, multinational surveillance study with molecular typing analysis. Methods: We evaluated the prevalence of methicillin resistance in S. aureus isolates in CA and healthcare-associated (HA) infections, and performed molecular characterization and antimicrobial susceptibility tests of MRSA isolates. Results: MRSA accounted for 25.5% of CA S. aureus infections and 67.4% of HA infections. Predominant clones of CA-MRSA isolates were ST59-MRSA-SCCmec type IV-spa type t437, ST30-MRSA-SCCmec type IV-spa type t019 and ST72-MRSA-SCCmec type IV-spa type t324. Previously established nosocomial MRSA strains including sequence type (ST) 239 and ST5 clones were found among CA-MRSA isolates from patients without any risk factors for HA-MRSA infection. CA-MRSA clones such as ST59, ST30 and ST72 were also isolated from patients with HA infections. Conclusions: Our findings confirmed that MRSA infections in the community have been increasing in Asian countries. Data also suggest that various MRSA clones have spread between the community and hospitals as well as between countries.
基金：
Asia Pacific Foundation for Infectious Diseases (APFID); Johnson JohnsonJohnson & Johnson USA; PfizerPfizer
第一作者机构：[1]Sungkyunkwan Univ Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea;[2]APFID, Seoul, South Korea;
通讯作者：
通讯机构：[1]Sungkyunkwan Univ Sch Med, Samsung Med Ctr, Div Infect Dis, Seoul, South Korea;[2]APFID, Seoul, South Korea;
推荐引用方式(GB/T 7714)：
Song Jae-Hoon,Hsueh Po-Ren,Chung Doo Ryeon,et al.Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study[J].JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY.2011,66(5):1061-1069.doi:10.1093/jac/dkr024.
APA：
Song, Jae-Hoon,Hsueh, Po-Ren,Chung, Doo Ryeon,Ko, Kwan Soo,Kang, Cheol-In...&Pham Hung Van.(2011).Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study.JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY,66,(5)
MLA：
Song, Jae-Hoon,et al."Spread of methicillin-resistant Staphylococcus aureus between the community and the hospitals in Asian countries: an ANSORP study".JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 66..5(2011):1061-1069
