机构：[1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China神经科系统神经内科首都医科大学宣武医院
Introduction Alzheimer's disease (AD) is associated with altered metabolites. This study aimed to determine the validity of using circulating metabolites to differentiate AD from other dementias. Methods Blood metabolites were measured in three data sets. Data set 1 (controls, 27; AD, 28) was used for analyzing differential metabolites. Data set 2 (controls, 93; AD, 92) was used to establish a diagnostic AD model with use of a metabolite panel. The model was applied to Data set 3 (controls, 76; AD, 76; other dementias, 205) to verify its capacity for differentiating AD from other dementias. Results Data set 1 revealed 7 upregulated and 77 downregulated metabolites. In Data set 2, a panel of 11 metabolites was included in a model that could distinguish AD from controls. In Data set 3, this panel was used to successfully differentiate AD from other dementias. Discussion This study revealed an AD-specific panel of 11 metabolites that may be used for AD diagnosis.
基金：
BeijingMunicipal Science & Technology Commission, Grant/Award Number:
Z201100005520016; National Natural Science Foundation of China, Grant/Award Numbers: 81870825, 82071194; BeijingMunicipal
Natural Science Foundation, Grant/Award
Number: 7202061
第一作者机构：[1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China[*1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, CapitalMedical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun St., Beijing 100000, China
通讯作者：
通讯机构：[1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing, China[*1]Innovation Center for Neurological Disorders and Department of Neurology, Xuanwu Hospital, CapitalMedical University, National Clinical Research Center for Geriatric Diseases, 45 Changchun St., Beijing 100000, China
推荐引用方式(GB/T 7714)：
Jia Longfei,Yang Jianwei,Zhu Min,et al.A metabolite panel that differentiates Alzheimer's disease from other dementia types[J].ALZHEIMERS & DEMENTIA.2022,18(7):1345-1356.doi:10.1002/alz.12484.
APA：
Jia, Longfei,Yang, Jianwei,Zhu, Min,Pang, Yana,Wang, Qi...&Wei, Yiping.(2022).A metabolite panel that differentiates Alzheimer's disease from other dementia types.ALZHEIMERS & DEMENTIA,18,(7)
MLA：
Jia, Longfei,et al."A metabolite panel that differentiates Alzheimer's disease from other dementia types".ALZHEIMERS & DEMENTIA 18..7(2022):1345-1356
医学