研究单位：[1]Renji Hospital, School of Medicine, Shanghai Jiaotong University,RenJi Hospital[2]Southern Medical University, China[3]First Affiliated Hospital of Zhejiang University[4]904th Hospital of the Joint Logistics Support Force of the PLA[5]Shenzhen Second People's Hospital[6]Huashan Hospital[7]Shanghai East Hospital[8]Xuanwu Hospital, Beijing[9]Beijing Tiantan Hospital[10]Peking Union Medical College Hospital[11]South Taihu Hospital Affiliated to Huzhou College[12]Second Affiliated Hospital of Wenzhou Medical University[13]The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School[14]The General Hospital of Eastern Theater Command[15]The First Affiliated Hospital with Nanjing Medical University[16]Yangzhou University[17]The Affiliated Hospital of Xuzhou Medical University[18]The First Affiliated Hospital of Soochow University[19]Zhongshan Hospital Of Traditional Chinese Medicine[20]Nanfang Hospital, Southern Medical University[21]First Affiliated Hospital of Xinjiang Medical University[22]West China Hospital[23]The Affiliated Hospital Of Southwest Medical University[24]The Second Affiliated Hospital of Air Force Medical University[25]Qilu Hospital of Shandong University[26]The Fourth Affiliated Hospital of China Medical University[27]Ganzhou People's Hospital[28]Xiangya Hospital of Central South University[29]Tongji Hospital[30]First Affiliated Hospital of Harbin Medical University[31]Henan Provincial People's Hospital[32]The Second People's Hospital of Anhui Province[33]The First Affiliated Hospital of University of Science and Technology of China[34]First Affiliated Hospital of Fujian Medical University[35]The Southwest Hospital of Army Medical University[36]Shanghai Donglei Brain Hospital[37]The Second Hospital & Clinical Medical School, Lanzhou University[38]General Hospital of Ningxia Medical University[39]The First Affiliated Hospital of University of Science and Technology of China,Hefei 1808722,Anhui 1818058,China[40]The Second People''s Hospital of Anhui Province,Hefei 1808722,Anhui 1818058,China[41]Beijing Tiantan Hospital Capital Medical University,Beijing 1816670,Beijing Municipality 2038349,China[42]Peking Union Medical College Hospital,Beijing 1816670,Beijing Municipality 2038349,China[43]Xuanwu Hospital Capital Medical University,Beijing 1816670,Beijing Municipality 2038349,China[44]The southwest hospital of Army medical university,Chongqi,Chongqing Municipality 1814905,China[45]The First Affiliated Hospital of Fujian Medical University,Fuzhou 1810821,Fujian 1811017,China[46]The Second Hospital & Clinical Medical School, Lanzhou University,Lanzhou 1804430,Gansu 1810676,China[47]Nanfang Hospital, Southern Medical University,Guangzhou 1809858,Guangdong 1809935,China[48]Zhujiang Hospital of Southern Medical University,Guangzhou 1809858,Guangdong 1809935,China[49]Shenzhen Second People''s Hospital,Shenzhen 1795565,Guangdong 1809935,China[50]Zhongshan Hospital of Traditional Chinese Medicine,Zhongshan 6986104,Guangdong 1809935,China[51]The First Affiliated Hospital of Harbin Medical University,Harbin 2037013,Heilongjiang 2036965,China[52]Henan Provincial People''s Hospital,Zhengzhou 1784658,Henan 1808520,China[53]Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology,Wuhan 1791247,Hubei 1806949,China[54]Xiangya Hospital of Central South University,Changsha 1815577,Hunan 1806691,China[55]General Hospital of Eastern Theater Command,Nanjing 1799962,Jiangsu 1806260,China[56]Jiangsu Province Hospital,Nanjing 1799962,Jiangsu 1806260,China[57]Nanjing Drum Tower Hospital,Nanjing 1799962,Jiangsu 1806260,China[58]The First Affiliated Hospital of Soochow University,Suzhou 1886760,Jiangsu 1806260,China[59]904 Hospital of the People''s Liberation Army Joint Logistic Support Force,Wuxi 1790923,Jiangsu 1806260,China[60]The Affiliated Hospital of Xuzhou Medical University,Xuzhou 10630003,Jiangsu 1806260,China[61]Affiliated Hospital of Yangzhou University,Yangzhou 1787227,Jiangsu 1806260,China[62]Ganzhou People''s Hospital,Ganzhou 1810638,Jiangxi 1806222,China[63]The Fourth Affiliated Hospital of China Medical University,Shenyang 2034937,Liaoning 2036115,China[64]General Hospital of Ningxia Medical University,Yinchuan 1786657,Ningxia 1799355,China[65]The Second Affiliated Hospital of Air Force Medical University,Xi''an 1790630,Shaanxi 1796480,China[66]Qilu Hospital of Shandong University,Jinan 1805753,Shandong 1796328,China[67]Huashan Hospital,Shanghai 1796236,Shanghai Municipality 1796231,China[68]Renji Hospital, School of Medicine, Shanghai Jiaotong University,Shanghai 1796236,Shanghai Municipality 1796231,China[69]Shanghai Donglei Brain Hospital,Shanghai 1796236,Shanghai Municipality 1796231,China[70]Shanghai East Hospital,Shanghai 1796236,Shanghai Municipality 1796231,China[71]West China Hospital, Sichuan University,Chengdu 1815286,Sichuan 1794299,China[72]The Affiliated Hospital of Southwest Medical University,Luzhou 1801640,Sichuan 1794299,China[73]The First Affiliated Hospital of Xinjiang Medical University,Ürümqi 1529102,Xinjiang Uygur Autonomous Region,China[74]First Affiliated Hospital of Zhejiang University,Hangzhou 1808926,Zhejiang 1784764,China[75]South taihu hospital affiliated to huzhou college,Huzhou 1806535,Zhejiang 1784764,China[76]The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou 1791388,Zhejiang 1784764,China
Ventriculitis is a severe infectious disease of the central nervous system with diverse etiologies. Currently, the treatment for ventriculitis is challenging, with poor prognosis. The mortality rate of ventriculitis is generally reported to be higher than 30%, with the highest reaching over 75%. Even among survivors, over 60% suffer from a variety of neurological sequelae, including cognitive impairment, gait disturbances, paralysis, behavioral disorders, and epilepsy. Currently, treatments for ventriculitis recommended by guidelines primarily focus on the selection and administration of antibiotics, while the effects of surgical interventions have not been fully elucidated. In recent years, several studies have explored the use of ventricular irrigation in ventriculitis, indicating that ventricular irrigation techniques may accelerate the control of ventricular infection, mitigate damage to the central nervous system caused by infections, improve the prognosis of ventriculitis, and reduce complications such as hydrocephalus. However, current studies are still relatively scarce, and mostly case reports and retrospective studies. High-quality evidence is still lacking for the application of ventricular irrigation in ventriculitis. This multicenter randomized controlled trial aims to explore the safety and effectiveness of ventricular irrigation compared to conventional treatment for ventriculitis, analyze the effectiveness of ventricular irrigation across different pathogen subgroups, and investigate independent risk factors for different prognostic states in patients with ventriculitis.
