机构：[1]College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China[2]Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China首都医科大学宣武医院
Tumors are genetically heterogeneous and many mutations are actually present in subclonal populations. The clonal status of mutations is valuable for accurate prognosis, clinical management. The aim of this study was to identify the clonal status of somatic mutations and systematically evaluate their prognostic values across various cancer types. We totally identified 227 clonal and 432 subclonal mutations contributed to prognosis and demonstrated the importance of clonal status in improving mutation-related clinical guidance. We further developed a customized multi-step approach to identify gene-specific prognostic patterns of clonal status at pan -cancer level and found some cancer-specific prognostic patterns. The 'subclonal-dependent risk' subpattern was one of the most common subpatterns, it usually accompanied by high genomic in-stability and high extent of intra-tumor heterogeneity and could be used to improve the accuracy of prognostic analysis. Our results revealed the importance of clonal status, especially subclonal mutation in clinical survival.
基金：
National Natural Science Foundation of China [32000459, 32170675]; special funds for the construction of higher education in Heilongjiang Province [UNPYSCT-2018068]; Heilongjiang Postdoctoral Scientific Research Developmental Fund [LBH-Q20147]
第一作者机构：[1]College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Cheng Peng,Lan Yujia,Liao Jianlong,et al.Systematic investigation of the prognostic impact of clonal status of somatic mutations across multiple cancer types[J].GENOMICS.2022,114(4):doi:10.1016/j.ygeno.2022.110412.
APA：
Cheng, Peng,Lan, Yujia,Liao, Jianlong,Zhao, Erjie,Yan, Haoteng...&Xu, Jinyuan.(2022).Systematic investigation of the prognostic impact of clonal status of somatic mutations across multiple cancer types.GENOMICS,114,(4)
MLA：
Cheng, Peng,et al."Systematic investigation of the prognostic impact of clonal status of somatic mutations across multiple cancer types".GENOMICS 114..4(2022)
