机构：[1]Henan Neurodevelopment Engineering Research Center for Children, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China[2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China神经科系统神经内科首都医科大学宣武医院[3]Department of Hematology and Oncology, Children's Hospital Affiliated to Zhengzhou University, Henan, Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, China[4]Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou University, Zhengzhou, China[5]Centre for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Circulating monocytes are precursors of both tissue macrophages and dendritic cells, and they can infiltrate the central nervous system (CNS) where they transform into bone marrow-derived macrophages (BMDMs). BMDMs play essential roles in various CNS diseases, thus modulating BMDMs might be a way to treat these disorders because there are currently no efficient therapeutic methods available for most of these neurological diseases. Moreover, BMDMs can serve as promising gene delivery vehicles following bone marrow transplantation for otherwise incurable genetic CNS diseases. Understanding the distinct roles that BMDMs play in CNS diseases and their potential as gene delivery vehicles may provide new insights and opportunities for using BMDMs as therapeutic targets or delivery vehicles. This review attempts to comprehensively summarize the neurological diseases that might be treated by modulating BMDMs or by delivering gene therapies via BMDMs after bone marrow transplantation.
基金：
Swedish Governmental grants to scientists working in health care [ALFGBG-965197]; National Nature Science Foundation of China [U21A20347]; Swedish Cancer Foundation [20-1121-PjF]; Swedish Childhood Cancer Foundation [PR2018-0082, PR2021-0020]
第一作者机构：[1]Henan Neurodevelopment Engineering Research Center for Children, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China[*1]Henan Neurodevelopment Engineering Research Center for Children, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
通讯作者：
通讯机构：[1]Henan Neurodevelopment Engineering Research Center for Children, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China[4]Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou University, Zhengzhou, China[5]Centre for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden[*1]Henan Neurodevelopment Engineering Research Center for Children, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.[*2]Henan Key Laboratory of Child Brain Injury and Henan Pediatric Clinical Research Center, The Third Affiliated Hospital and Institute of Neuroscience, Zhengzhou University, Zhengzhou 450052, China (or) Center for Brain Repair and Rehabilitation, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg 40530, Sweden
推荐引用方式(GB/T 7714)：
Zhou Kai,Han Jinming,Wang Yafeng,et al.The therapeutic potential of bone marrow-derived macrophages in neurological diseases[J].CNS NEUROSCIENCE & THERAPEUTICS.2022,28(12):1942-1952.doi:10.1111/cns.13964.
APA：
Zhou, Kai,Han, Jinming,Wang, Yafeng,Xu, Yiran,Zhang, Yaodong&Zhu, Changlian.(2022).The therapeutic potential of bone marrow-derived macrophages in neurological diseases.CNS NEUROSCIENCE & THERAPEUTICS,28,(12)
MLA：
Zhou, Kai,et al."The therapeutic potential of bone marrow-derived macrophages in neurological diseases".CNS NEUROSCIENCE & THERAPEUTICS 28..12(2022):1942-1952
