机构：[1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China 神经科系统神经内科首都医科大学宣武医院[2]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China [3] Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100053, China
Cerebrovascular disease is highly prevalent and has a complex etiology and variable pathophysiological activities. It thus poses a serious threat to human life and health. Currently, pathophysiological research on cerebrovascular diseases is gradually improving, and oxidative stress and autophagy have been identified as important pathophysiological activities that are gradually attracting increasing attention. Many studies have found some effects of oxidative stress and autophagy on cerebrovascular diseases, and studies on the crosstalk between the two in cerebrovascular diseases have made modest progress. However, further, more detailed studies are needed to determine the specific mechanisms. This review discusses nuclear factor erythroid 2-related factor 2 (Nrf2) molecules, which are closely associated with oxidative stress and autophagy, and the crosstalk between them, with the aim of providing clues for studying the two important pathophysiological changes and their crosstalk in cerebrovascular diseases as well as exploring new target treatments.
基金：
Natural Science Foundation in China [82001390, 82171301]
第一作者机构：[1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[1]Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China [2]Beijing Municipal Geriatric Medical Research Center, Beijing 100053, China [3] Beijing Institute for Brain Disorders, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Hu Yue,Luo Yumin,Zheng Yangmin.Nrf2 Pathway and Autophagy Crosstalk: New Insights into Therapeutic Strategies for Ischemic Cerebral Vascular Diseases[J].ANTIOXIDANTS.2022,11(9):doi:10.3390/antiox11091747.
APA：
Hu, Yue,Luo, Yumin&Zheng, Yangmin.(2022).Nrf2 Pathway and Autophagy Crosstalk: New Insights into Therapeutic Strategies for Ischemic Cerebral Vascular Diseases.ANTIOXIDANTS,11,(9)
MLA：
Hu, Yue,et al."Nrf2 Pathway and Autophagy Crosstalk: New Insights into Therapeutic Strategies for Ischemic Cerebral Vascular Diseases".ANTIOXIDANTS 11..9(2022)
