机构：[1]Department of Nephrology, Peking University Third Hospital, Beijing, China.[2]Department of Pharmacy, Peking University Third Hospital, Beijing, China.[3]Department of Nephrology, Xuanwu Hospital Capital Medical University, Beijing, China.内科系统肾科首都医科大学宣武医院
Vascular calcification (VC) is high prevalent and predicts cardiovascular mortality in dialysis patients. The mechanisms are not known clearly. Trimethylamine-N-oxide (TMAO), a gut-microbiota derivate metabolite, is also associated with cardiovascular outcomes in hemodialysis (HD) patients. This study aims to evaluate serum TMAO levels and establish their relation to VC in HD patients.Serum TMAO concentrations were measured by high-performance liquid chromatography-mass spectrometry. Vascular calcification was evaluated by abdominal aortic calcification (AAC) scores. Taking the AAC score value 5.5 as the cutoff value, the participants were divided into the high AAC score group and the low AAC score group.A total of 184 HD patients and 39 healthy controls were enrolled in this cross-sectional study. Serum Ln(TMAO) (the natural logarithm of TMAO) concentrations were significantly higher in HD patients than that of control subjects (1.82 ± 0.62 vs. -1.60 ± 0.77, p < 0.001). Compared with the group with low AAC scores, the HD patients with high AAC scores showed significantly higher serum Ln(TMAO) levels (2.09 ± 0.55 vs. 1.67 ± 0.54, p < 0.001). In the multivariate regression analysis, serum Ln(TMAO), HD vintage, with diabetic mellitus, age and plasma intact parathyroid hormone (iPTH) were independent determinant factors for VC in HD patients.Higher serum TMAO levels, older age, longer HD vintage, higher plasma iPTH and with diabetes mellitus were independent risk factors for VC in HD patients. The underlying mechanism deserves further investigations and the finding hints at a new target for the treatment of VC.
基金：
National Natural Science
Foundation (Grant No. 81873619, Grant No. 81570663) to
Aihua Zhang, Research Initiation Fund for the Excellent
Returned Overseas Scholars of Peking University Third
Hospital (Grant No. BYSYLXHG2019007) to Wenling Yang,
and the Key Program of Peking University Third Hospital
(Grant No. BYSY2018024) to Lian He.
第一作者机构：[1]Department of Nephrology, Peking University Third Hospital, Beijing, China.
通讯作者：
通讯机构：[1]Department of Nephrology, Peking University Third Hospital, Beijing, China.[3]Department of Nephrology, Xuanwu Hospital Capital Medical University, Beijing, China.[*1]Department of Nephrology, Xuanwu Hospital Capital Medical University, 45 Changchun Rd, Xicheng District, Beijing 100053, China[*2]Department of Nephrology, Peking University Third Hospital, 49 North Garden Rd, Haidian District, Beijing 100191, China
推荐引用方式(GB/T 7714)：
He Lian,Yang Wenling,Yang Ping,et al.Higher serum trimethylamine-N-oxide levels are associated with increased abdominal aortic calcification in hemodialysis patients[J].RENAL FAILURE.2022,44(1):2019-2027.doi:10.1080/0886022X.2022.2145971.
APA：
He Lian,Yang Wenling,Yang Ping,Zhang Xianhua&Zhang Aihua.(2022).Higher serum trimethylamine-N-oxide levels are associated with increased abdominal aortic calcification in hemodialysis patients.RENAL FAILURE,44,(1)
MLA：
He Lian,et al."Higher serum trimethylamine-N-oxide levels are associated with increased abdominal aortic calcification in hemodialysis patients".RENAL FAILURE 44..1(2022):2019-2027
