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Neuroimaging biomarkers of small vessel disease in cerebral amyloid angiopathy-related intracerebral hemorrhage

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机构： [1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China [2]Department of Neurology, Beijing Shijitan hospital, Capital Medical University, Beijing, China [3]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China [4]Department of Neurosurgery, Beijing Fengtai You'anmen Hospital, Beijing, China [5]Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China [6]Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China

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关键词： cerebral amyloid angiopathy cerebral hemorrhage cerebral small vessel diseases neuroimaging

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AimsThe significance of the correlation of computed tomography (CT)-based cerebral small vessel disease (SVD) markers with the clinical outcomes in patients with cerebral amyloid angiopathy (CAA)-related intracerebral hemorrhage (ICH) remains uncertain. Thus, this study aimed to explore the relationship between SVD markers and short-term outcomes of CAA-ICH. MethodsA total of 183 patients with CAA-ICH admitted to the Xuanwu Hospital, and Beijing Fengtai You'anmen Hospital, from 2014 to 2021 were included. The multivariate logistic regression analysis was performed to identify the correlation between SVD markers based on CT and clinical outcomes at 7-day and 90-day. ResultsOf the 183 included patients, 66 (36%) were identified with severe SVD burden. The multivariate analysis showed that the total SVD burden, white matter lesion (WML) grade, and brain atrophy indicator were independent risk factors for unfavorable outcomes at 90-day. The brain atrophy indicator was independently associated with mortality at 90-day. Severe cortical atrophy was significantly associated with early neurological deterioration. ConclusionsThe neuroimaging profiles of SVD based on CT in patients with CAA-ICH might predict the short-term outcome more effectively. Further studies are required to validate these findings and identify modifiable factors for preventing CAA-ICH development.

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出版当年[2022]版：

大类 | 1 区

医学

小类 | 1 区药学 1 区神经科学

最新[2023]版：

大类 | 1 区医学

小类 | 2 区神经科学 2 区药学

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出版当年[2021]版：

Q1 NEUROSCIENCES Q1 PHARMACOLOGY & PHARMACY

最新[2023]版：

Q1 PHARMACOLOGY & PHARMACY Q1 NEUROSCIENCES

影响因子： 4.8 最新[2023版] 5.9 最新五年平均 7.035 出版当年[2021版] 6.329 出版当年五年平均 5.243 出版前一年[2020版] 5.5 出版后一年[2022版]

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第一作者机构： [1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China

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通讯机构： [3]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Xuan Wu Hospital, Capital Medical University, Beijing, China [6]Department of Neurosurgery, Xuan Wu Hospital, Capital Medical University, Beijing, China [*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No 45, Changchun Street, Xicheng District, Beijing 100053, China.

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