The distribution profile of plasma homocysteine (Hcy) in young adults and its related factors are not well understood. We performed a generalized estimating equations (GEE) analysis for plasma-Hcy-correlated factors in 2436 young adults, aged 20-39 years, from a health checkup population. We observed that the mean Hcy concentration in males (16.7 ± 10.3 μmol/L) was significantly higher than that in females (10.3 ± 4.0 μmol/L), and hyperhomocysteinemia (HHcy) prevalence in males was 5.37 times than that in females (33.3% vs. 6.2%). A GEE analysis stratified by sex indicated that age (B = -0.398, p < 0.001) and LDL-C (B = -1.602, p = 0.043) were negatively correlated, while BMI (B = 0.400, p = 0.042) was positively correlated, with the Hcy level in young males. ALT (B = -0.021, p = 0.033), LDL-C (B = -1.198, p < 0.001) and Glu (B = -0.446, p = 0.006) were negatively correlated, while AST (B = 0.022, p = 0.048), CREA (B = 0.035, p < 0.001), UA (B = 0.004, p = 0.003) and TG (B = 1.042, p < 0.001) were positively correlated, with the Hcy level in young females. These results suggest that young males have a significantly higher plasma Hcy level and HHcy prevalence than young females; therefore, more attention should be paid to the reason for and effect of the higher HHcy prevalence in young males.
基金：
Beijing Municipal Key Laboratory of Clinical
Epidemiology, China; the National Natural Science Foundation of China, China (grant no. 81971200);
and the Beijing Municipal Natural Science Foundation, China (grant no. 7222082).
第一作者机构：[1]Information Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构：[3]Department of Evidence-Based Medicine, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.[4]Beijing Geriatric Healthcare Center, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Li Zhihua,Zhao Jing,Hou Chengbei,et al.Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations[J].JOURNAL OF CLINICAL MEDICINE.2023,12(4):doi:10.3390/jcm12041656.
APA：
Li Zhihua,Zhao Jing,Hou Chengbei,Sun Fei,Dong Jing...&Chu Xi.(2023).Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations.JOURNAL OF CLINICAL MEDICINE,12,(4)
MLA：
Li Zhihua,et al."Factors Related to Plasma Homocysteine Concentration in Young Adults: A Retrospective Study Based on Checkup Populations".JOURNAL OF CLINICAL MEDICINE 12..4(2023)
医学