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Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Wang Tao[1,2] * ; Wang Yuru[3] * ; Zhang Xiao[1,2] * ; Xu Wenlong[1,2] ; Jin Kehan[3] ; Pang Yiyun[3] ; Wu Yujie[4,5] ; Luo Jichang[1,2] ; Xu Ran[1,2,*1] ; Jiao Liqun[1,2,6,*2] ; Li Wenjing[4,5,*3] ;
机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [2]China International Neuroscience Institute (China-INI), Beijing, China [3]Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China [4]Laboratory of Computational Biology and Machine Intelligence, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China [5]School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China [6]Department of Interventional Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.arr.2023.101888
ISSN：

关键词： Atherosclerosis Oxidized phospholipid Chronic inflammation Signaling pathway Therapeutic target

摘要：
Vascular ageing is an important factor in the morbidity and mortality of the elderly. Atherosclerosis is a characteristic disease of vascular ageing, which is closely related to the enhancement of vascular inflammation. Phospholipid oxidation products are important factors in inducing cellular inflammation. Through interactions with vascular cells and immune cells, they regulate intracellular signaling pathways, activate the expression of various cytokines, and affect cell behavior, such as metabolic level, proliferation, apoptosis, etc. Intervention in lipid metabolism and anti-inflammation are the two key pathways of drugs for the treatment of atherosclerosis. This review aims to sort out the signaling pathway of oxidized phospholipids-induced inflammatory factors in vascular cells and immune cells and the mechanism leading to changes in cell behavior, and summarize the therapeutic targets in the inflammatory signaling pathway for the development of atherosclerosis drugs.Copyright © 2023 Elsevier B.V. All rights reserved.

基金：
National Natural Science Foundation of China (Grant Nos. 82171303 and 91954201), the Beijing Hospitals Authority’s Ascent Plan (DFL20220702), and the Beijing Municipal Science & Technology Commission (Grant No. 5202022).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
最新[2025]版：
大类 | 1 区 医学
小类 | 1 区 老年医学 2 区 细胞生物学
JCR分区：
出版当年[2021]版：
Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY
最新[2023]版：
Q1 CELL BIOLOGY Q1 GERIATRICS & GERONTOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [2]China International Neuroscience Institute (China-INI), Beijing, China
共同第一作者：
通讯作者：
通讯机构： [1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [2]China International Neuroscience Institute (China-INI), Beijing, China [4]Laboratory of Computational Biology and Machine Intelligence, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China [5]School of Artificial Intelligence, University of Chinese Academy of Sciences, Beijing, China [6]Department of Interventional Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China [*1]China International Neuroscience Institute (China-INI), Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Ave, Xicheng District, Beijing 100053, China. [*2]China International Neuroscience Institute (China-INI), Department of Neurosurgery and Department of Interventional Neuroradiology, Xuanwu Hospital, Capital Medical University, No. 45 Changchun Street, Xicheng District, Beijing 100053, China. [*3]Laboratory of Computational Biology and Machine Intelligence, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences.School of Artificial Intelligence, University of Chinese Academy of Sciences, No. 95 Zhongguancun East Road, Haidian District, Beijing, China.
推荐引用方式(GB/T 7714)：
Wang Tao,Wang Yuru,Zhang Xiao,et al.Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing[J].AGEING RESEARCH REVIEWS.2023,86:doi:10.1016/j.arr.2023.101888.
APA：
Wang Tao,Wang Yuru,Zhang Xiao,Xu Wenlong,Jin Kehan...&Li Wenjing.(2023).Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing.AGEING RESEARCH REVIEWS,86,
MLA：
Wang Tao,et al."Mechanism of oxidized phospholipid-related inflammatory response in vascular ageing".AGEING RESEARCH REVIEWS 86.(2023)

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